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ENDOCRINE PANCREAS
Summary
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Key words: beta cells, immunosuppression, pancreas regeneration, stem cells
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Pluripotens ESC
Mesoderma- sejtek
Definitív endoderma
Primitív előbél
Pancreas- endoderma
Endocrin sejtek
Aktivin A + Wnt3a
Aktivin A Ciklopamin + FGF10
Ciklopamin + FGF10 + retinsav + Notch-gátló
Exendin-4 + IGF1 + HGF Az emberi egyedfejlődés során: 12-13 hét
In vitro differenciáltatás: 15–18 nap
100% 80% 80% 50% 35%
13–15% egyéb endocrin sejt 7–12% inzulintermelő sejt
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Autoimmun támadás
Krónikus gyulladás, gluko(lipo)toxicitás, inzulinrezisztencia
Transzdifferenciálódás
Acinussejtek Exendin-4, aktivin A, HGF
PDX1, NGN3, MAFA PDX1, NGN3, NEUROD1
Pancreas- őssejtek
HSC és MSC
Exendin-4, GLP1, HGF
β β
1-es típusú diabetes mellitus 2-es típusú diabetes mellitus
Hepatocyták Ductalis sejtek
A β-sejtek proliferációja Osztódás és differenciálódás
Transzdifferenciálódás
Osztódás
Differenciálódás
Transzdifferenciálódás
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