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$',$%(7(60(//,786Ę66(-77(5É3,É-$² AZ ENDOCRIN PANCREAS REGENERÁCIÓJA

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Academic year: 2022

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ENDOCRINE PANCREAS

Summary

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Key words: beta cells, immunosuppression, pancreas regeneration, stem cells

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Pluripotens ESC

Mesoderma- sejtek

Definitív endoderma

Primitív előbél

Pancreas- endoderma

Endocrin sejtek

Aktivin A + Wnt3a

Aktivin A Ciklopamin + FGF10

Ciklopamin + FGF10 + retinsav + Notch-gátló

Exendin-4 + IGF1 + HGF Az emberi egyedfejlődés során: 12-13 hét

In vitro differenciáltatás: 15–18 nap

100% 80% 80% 50% 35%

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