drug-treated and mutant fission yeast cells. Because the mechanism of localized growth and actin polymer-ization is not a special phenomenon of fission yeast cells, and because many genes that regulate growth zones are well conserved in evolution (Irazoqui and Lew, 2004; Johnson, 1999; Verde et al., 1998), we believe that our model can help to understand the regulation of polarized cell growth in higher eukaryotes as well.
Acknowledgements
We thank P. Nurse and many earlier and current members of his laboratory, especially J. Hayles, S. Castagnetti and K. Leonhard, for sharing ideas and helping model develop-ment. This work was supported by the James S. McDonnell Foundation (Grant No. 21002050), the European Commis-sion (Grant No. YSBN: LSHG-CT-018942) and OTKA (Grant No. F-60414).
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