Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P

(2002) Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J, 21:1743-1753

42. Thurston G, Rudge JS, Ioffe E, Zhou H, Ross L, Croll SD, Glazer N, Holash J, McDonald DM, Yancopoulos GD. (2000) Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med, 6:460-463

43. Allende ML, Proia RL. (2002) Sphingosine-1-phosphate receptors and the development of the vascular system. Biochim Biophys Acta, 1582:222-227

44. Timar J, Dome B, Fazekas K, Janovics A, Paku S. (2001) Angiogenesis-dependent diseases and angiogenesis therapy. Pathol Oncol Res, 7:85-94

106

45. Ferrara N. (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer, 2:795-803

46. Folkman J, Merler E, Abernathy C, Williams G. (1971) Isolation of a tumor factor responsible for angiogenesis. J Exp Med, 133:275-288

47. Gao N, Ding M, Zheng JZ, Zhang Z, Leonard SS, Liu KJ, Shi X, Jiang BH. (2002) Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem, 277:31963-31971

48. Gao N, Jiang BH, Leonard SS, Corum L, Zhang Z, Roberts JR, Antonini J, Zheng JZ, Flynn DC, Castranova V, Shi X. (2002) p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells. J Biol Chem, 277:45041-45048

49. Peng XH, Karna P, Cao Z, Jiang BH, Zhou M, Yang L. (2006) Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J Biol Chem, 281:25903-25914

50. Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. (2001) HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol, 21:3995-4004

51. Blancher C, Moore JW, Robertson N, Harris AL. (2001) Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway. Cancer Res, 61:7349-7355

52. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. (2002) Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol, 22:7004-7014 53. Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H. (2011) Src

activates HIF-1alpha not through direct phosphorylation of HIF-1alpha specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.

Carcinogenesis, 32:703-712

107

54. Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. (2000) Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev, 14:391-396

55. Rivera CG, Mellberg S, Claesson-Welsh L, Bader JS, Popel AS. (2011) Analysis of VEGF--a regulated gene expression in endothelial cells to identify genes linked to angiogenesis. PLoS One, 6:e24887

56. Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T. (2002) Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett, 512:157-162 57. Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons

JW, Semenza GL. (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res, 60:1541-1545

58. Watanabe T, Yasue A, Tanaka E. (2006) Inhibition of Transforming Growth Factor beta1 (TGF-beta1)/ Smad3 Signaling Decreases Hypoxia-Inducible Factor 1alpha (HIF-1alpha) Protein Stability by Inducing Prolyl Hydroxylase 2 (PHD2) Expression in Human Periodontal Ligament Cells. J Periodontol, 281(34):24171-81.

59. Haddad JJ, Land SC. (2001) A non-hypoxic, ROS-sensitive pathway mediates TNF-alpha-dependent regulation of HIF-1alpha. FEBS Lett, 505:269-274

60. Fleming RY, Ellis LM, Parikh NU, Liu W, Staley CA, Gallick GE. (1997) Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase. Surgery 122:501-507

61. Mayerhofer M, Valent P, Sperr WR, Griffin JD, Sillaber C. (2002) BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood, 100:3767-3775

62. Konishi T, Huang CL, Adachi M, Taki T, Inufusa H, Kodama K, Kohno N, Miyake M. (2000) The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers. Int J Oncol, 16:501-511

108

63. Fujisawa T, Watanabe J, Kamata Y, Hamano M, Hata H, Kuramoto H. (20039 Effect of p53 gene transfection on vascular endothelial growth factor expression in endometrial cancer cells. Exp Mol Pathol, 74:276-281

64. Maity A, Pore N, Lee J, Solomon D, O'Rourke DM. (2000) Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia. Cancer Res, 60:5879-5886

65. Warren RS, Yuan H, Matli MR, Ferrara N, Donner DB. (1996) Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J Biol Chem, 271:29483-29488

66. Kumar R, Yarmand-Bagheri R. (2001) The role of HER2 in angiogenesis. Semin Oncol, 28:27-32

67. Joo YE, Rew JS, Seo YH, Choi SK, Kim YJ, Park CS, Kim SJ. (2003) Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. J Clin Gastroenterol, 37:28-33

68. Dong J, Grunstein J, Tejada M, Peale F, Frantz G, Liang WC, Bai W, Yu L, Kowalski J, Liang X, Fuh G, Gerber HP, Ferrara N. (2004) VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis.

EMBO J, 23:2800-2810

72. Muller YA, Christinger HW, Keyt BA, de Vos AM. (1997) The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding. Structure, 5:1325-1338

73. DiSalvo J, Bayne ML, Conn G, Kwok PW, Trivedi PG, Soderman DD, Palisi TM, Sullivan KA, Thomas KA. (1995) Purification and characterization of a naturally

109

occurring vascular endothelial growth factor.placenta growth factor heterodimer. J Biol Chem, 270:7717-7723

74. Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L. (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem, J 437:169-183

75. Stuttfeld E, Ballmer-Hofer K. (2009) Structure and function of VEGF receptors.

IUBMB Life, 61:915-922