• Nem Talált Eredményt

3. fejezet

1. Pethő, G., Derow, A., Reeh, P.W.: Bradykinin-induced nociceptor sensitization to heat is mediated by cyclooxygenase products in isolated rat skin.

European Journal of Neuroscience, 14:210-218, 2001.

2. Reeh, P.W., Pethő, G.: Nociceptor exciation by thermal sensitization  a hypothesis.

Progress in Brain Research, 129:39-50, 2000.

3. Derow, A., Izydorczyk, I., Kuhn, A., Reeh, P.W., Pethő, G.: Prostaglandin E2 and I2 facilitate noxious heat-induced spike discharge but not iCGRP release from rat cutaneous nociceptors.

Life Sciences, 81:1685-1690, 2007.

4. Pethő, G., Izydorczyk, I., Reeh, P.W.: Effects of TRPV1 receptor antagonists on stimulated iCGRP release from isolated skin of rats and TRPV1 mutant mice.

Pain, 109:284-290, 2004.

4. fejezet

1. Almási, R., Pethő, G., Bölcskei, K, Szolcsányi, J.: Effect of resiniferatoxin on the noxious heat threshold temperature in the rat: a heat allodynia model sensitive to analgesics.

British Journal of Pharmacology, 139:49-58, 2003.

2. Bölcskei, K., Horváth, D., Szolcsányi, J., Pethő, G.: Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.

European Journal of Pharmacology, 564:80-87, 2007.

3. Füredi, R., Bölcskei, K., Szolcsányi, J., Pethő, G.: Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.

European Journal of Pharmacology, 605: 63-67, 2009.

4. Tékus, V., Bölcskei, K., Kis-Varga, A., Dézsi, L., Szentirmay, E., Visegrády, A., Horváth, C., Szolcsányi, J., Pethő, G.: Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.

European Journal of Pharmacology, 641:135-141, 2010.

5. Boros, M., Benkó, R., Bölcskei, K., Szolcsányi, J., Barthó, L., Pethő, G.: Effects of reference analgesics and psychoactive drugs on the noxious heat threshold of mice measured by an increasing-temperature water bath.

Basic and Clinical Pharmacology and Toxicology, 113:385–390, 2013.

5. fejezet

1. Füredi, R., Bölcskei, K., Szolcsányi, J., Pethő, G.: Comparison of the peripheral mediator background of heat injury- and plantar incision-induced drop of the noxious heat threshold in the rat.

Life Sciences, 86:244-250, 2010.

2. Szolcsányi, J., Sándor, Z., Pethő, G., Varga, A., Bölcskei, K., Almási, R., Riedl, Zs., Hajós, G., Czéh, G.: Direct evidence for activation and desensitization of the capsaicin receptor by N-oleoyldopamine on TRPV1-transfected cell line, in gene deleted mice and in the rat.

Neuroscience Letters, 361:155-158, 2004.

3. Almási, R., Szőke, É., Bölcskei, K., Varga, A., Riedl, Zs. Sándor, Z., Szolcsányi, J., Pethő, G.: Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo.

Life Sciences, 82:644-651, 2008.

4. Varga, A., Bölcskei, K., Szőke, É., Almási, R., Czéh, G., Szolcsányi, J., Pethő, G.: Relative roles of protein kinase A and protein kinase C in modulation of TRPV1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.

Neuroscience, 140:645-657, 2006.

5. Pethő, G., Bölcskei, K., Füredi, R., Botz, B., Bagoly, T., Pintér, E., Szolcsányi, J.: Evidence for a novel, neurohumoral antinociceptive mechanism mediated by peripheral capsaicin-sensitive nociceptors in conscious rats.

Neuropeptides, 62:1-10, 2017.

6. Tékus, V., Horváth, Á., Hajna, Z., Borbély, É., Bölcskei, K., Boros, M., Pintér, E., Helyes, Z., Pethő, G., Szolcsányi, J.: Noxious heat threshold temperature and pronociceptive effects of allyl isothiocyanate (mustard oil) in TRPV1 or TRPA1 gene-deleted mice.

Life Sciences, 154:66-74, 2016.

7. Bölcskei, K., Tékus, V., Dézsi, L., Szolcsányi, J., Pethő, G.: Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat.

European Journal of Pain, 14:480-486, 2010.

188 9. IRODALOMJEGYZÉK

Ahern GP. Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem 278:30429–30434, 2003.

Ahluwalia J, Rang H, Nagy I. The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons. Eur J Neurosci 16:1483–1489, 2002.

Ahluwalia J, Urban L, Bevan S, Nagy I. Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci 17:2611–2618, 2003.

Albin KC, Carstens MI, Carstens E. Modulation of oral heat and cold pain by irritant chemicals. Chem Senses 33:3–

15, 2008.

Alpizar YA, Boonen B, Gees M, Sanchez A, Nilius B, Voets T, Talavera K. Allyl isothiocyanate sensitizes TRPV1 to heat stimulation. Pflügers Arch 466:507–515, 2014.

Amabeoku GJ, Green I, Eagles P, Benjeddou M. Effects of Tarchonantus camphoratus and Eriocephalus africanus on nociception in mice and pyrexia in rats. Phytomedicine 7:517–522, 2000.

Amadesi S, Nie J, Vergnolle N, Cottrell GS, Grady EF, Trevisani M, Manni C, Geppetti P, McRoberts JA, Ennes H, Davis JB, Mayer EA, Bunnett NW. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 24:4300–4312, 2004.

Amann R, Maggi CA. Ruthenium red as a capsaicin antagonist. Life Sci 49:849–856, 1991.

Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth 107:490-502, 2011.

Ankier SI. New hot plate tests to quantify antinociceptive and narcotic antagonist activities. Eur J Pharmacol 27:1–

4, 1974.

Babes A, Zorzon D, Reid G. Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. Eur J Neurosci 20:2276–2282, 2004.

Balcombe JP, Barnard ND. Sandusky C Laboratory routines cause animal stress. Contemp Top Lab Anim Sci 43:42–51, 2004.

Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849–857, 2004.

Banik RK, Brennan TJ. Spontaneous discharge and increased heat sensitivity of rat C-fiber nociceptors are present in vitro after plantar incision. Pain 112:204–213, 2004.

Banik RK, Brennan TJ. TRPV1 mediates spontaneous firing and heat sensitization of cutaneous primary afferents after plantar incision. Pain 141:41–51, 2009.

Banks WA, Kastin AJ. Peptide transport systems for opiates across the bloodbrain barrier. Am J Physiol 259:E1–

E10, 1990.

Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124:1269–1282, 2006.

Bautista DM, Siemens J, Glazer JM, Tsuruda PR, Basbaum AI, Stucky CL, Jordt SE, Julius D. The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448:204–208, 2007.

Ben-Bassat J, Peretz E, Sulman FG. Analgesimetry and ranking of analgesic drugs by the receptacle method. Arch Int Pharmacodyn Ther 122:434–447, 1959.

Benoist JM, Pincedé I, Ballantyne K, Plaghki L, Le Bars D. Peripheral and central determinants of a nociceptive reaction: an approach to psychophysics in the rat. PLoS One 3:e3125, 2008.

Berg J, Fellier H, Christoph T, Kremminger P, Hartmann M, Blaschke H, Rovensky F, Towart R, Stimmeder D.

Pharmacology of a selective cyclooxygenase-2 inhibitor, HN-56249: a novel compound exhibiting a marked preference for the human enzyme in intact cells. N-S Arch Pharmacol 361:363–372, 2000.

Berge OG, Garcia-Cabrera I, Hole K. Response latencies in the tail-flick test depend on tail skin temperature.

Neurosci Lett 86:284–288, 1988.

Bessou P, Perl ER. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32:1025–1043, 1969.

Bevan SJ, Hothi S, Hughes G, James IF, Rang HP. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol 107:544–552, 1992.

Bhave G, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW IV. cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35:721–731, 2002.

Bhave G, Hu HJ, Glauner KS, Zhu W, Wang H, Brasier DJ, Oxford GS, Gereau RW 4th. Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci USA 100:12480–12485, 2003.

Bianchi M, Panerai AE. The dose-related effects of paracetamol on hyperalgesia and nociception in the rat. Br J Pharmacol 117:130–132, 1996.

Biddlestone L, Corbett AD, Dolan S. Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain. Br J Pharmacol 151:285–291, 2007.

Birrell GJ, McQueen DS, Iggo A, Grubb BD. Prostanoid-induced potentiation of the excitatory and sensitizing effects of bradykinin on articular mechanonociceptors in the rat ankle joint. Neuroscience 54:537–544, 1993.

Bittner MA, Lahann TR. Biphasic time-course of capsaicin-induced substance P depletion: failure to correlate with thermal analgesia in the rat. Brain Res 322:305–309, 1984.

Bjorkman R, Hedner J, Hedner T, Henning M. Central, naloxone-reversible antinociception by diclofenac in the rat.

N-S Arch Pharmacol 342:171–176, 1990.

Bonet IJ, Fischer L, Parada CA, Tambeli CH. The role of transient receptor potential A 1 (TRPA1) in the development and maintenance of carrageenan-induced hyperalgesia. Neuropharmacology 65:206–212, 2013.

Bonnington JK, McNaughton PA. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J Physiol 551:433–446, 2003.

Bonnycastle DD, Cook L, Ipsen J. The action of some analgesic drugs in intact and chronic spinal rats. Acta Pharmacol Toxicol 9:332–336, 1953.

Bourke DL. Counter-irritation reduces pain during cutaneous needle insertion. Anesth Analg 64:379, 1985.

Bölcskei K, Helyes Z, Szabó Á, Sándor K, Elekes K, Németh J, Almási R, Pintér E, Pethő G, Szolcsányi J.

Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain 117:368–376, 2005.

Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain. Pain 64:493–501, 1996.

Bretag A. Synthetic interstitial fluid for isolated mammalian tissue. Life Sci 8:319–329, 1969.

Brock JA, McLachlan EM, Belmonte C. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol 512:211–217, 1998.

Bromm B, Jahnke MT, Treede RD. Responses of human cutaneous afferents to CO2 laser stimuli causing pain. Exp Brain Res 55:158–166, 1984.

Brown AG, Iggo A. A quantitative study of cutaneous receptors and afferent fibres in the cat and rabbit. J Physiol 193:707–733, 1967.

Brune K, Beck WS, Geisslinger G, Menzel-Soglowek S, Peskar BM, Peskar BA. Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia 47:257–261, 1991.

Buettner K. Effects of extreme heat and cold on human skin. II. Surface temperature, pain and heat conductivity in experiments with radiant heat. J Appl Physiol 3:703–713, 1951.

Bukhari IA, Khan RA, Gilani AH, Ahmed S, Saeed SA. Analgesic, anti-inflammatory and anti-platelet activities of the methanolic extract of Acacia modesta leaves. Inflammopharmacol 18:187–196, 2010.

Burgess PR, Perl ER. Myelinated afferent fibres responding specifically to noxious stimulation of the skin. J Physiol 190:541–562, 1967.

Burgess GM, Mullaney I, Mcneil M, Dunn PM, Rang HP. Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J Neurosci 9:3314–3325, 1989.

Cain DM, Khasabov SG, Simone DA. Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study. J Neurophysiol 85:1561–1574, 2001.

Campbell JN, LaMotte RH. Latency to detection of first pain. Brain Res 266:203–208, 1983.

Campero M, Serra J, Ochoa JL. C-polymodal nociceptors activated by noxious low temperature in human skin. J Physiol 497:565–572, 1996.

Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity.

Science 322:590–594, 2008.

Carlton SM, Coggeshall RE. Immunohistochemical localization of enkephalin in peripheral sensory axons in the rat.

Neurosci Lett 221:121–124, 1997.

Carlton SM, Du J, Davidson E, Zhou S, Coggeshall RE. Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors. Pain 90:233–244, 2001a.

Carlton SM, Du J, Zhou S, Coggeshall RE. Tonic control of peripheral cutaneous nociceptors by somatostatin receptors. J Neurosci 21:4042–4049, 2001b.

Carlton SM, Zhou S, Kraemer B, Coggeshall RE. A role for peripheral somatostatin receptors in counter-irritation-induced analgesia. Neuroscience 120:499–508, 2003.

Carlton SM. Nociceptive primary afferents: they have a mind of their own. J Physiol 592:3403–3411, 2014.

Carney SA, Hall M, Ricketts CR. The adenosine triphosphate content and lactic acid production of guinea-pig skin after mild heat damage. Br J Dermatol 94:291–294, 1976.

Carroll MN. The effect of injury in nociceptive tests employed in analgetic assays. Arch Int Pharmacodyn Ther 123:48–57, 1959.

Carstens E, Wilson C. Rat tail flick reflex: magnitude measurement of stimulus-response function, suppression by morphine and habituation. J Neurophysiol 70:630–639, 1993.

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824, 1997.

Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436–441, 1999.

190

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306–313, 2000.

Cesare P, McNaughton P. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.

Proc Natl Acad Sci USA 93:15435–15439, 1996.

Cesare P, Dekker LV, Sardini A, Parker PJ, McNaughton PA. Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron 23:617–624, 1999.

Chen Y, Yang C, Wang ZJ. Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain. Neuroscience 193:440–51, 2011.

Chizh BA, O'Donnell MB, Napolitano A, Wang J, Brooke AC, Aylott MC, Bullman JN, Gray EJ, Lai RY, Williams PM, Appleby JM. The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 132:132–141, 2007.

Chizh BA, Sang CN. Use of sensory methods for detecting target engagement in clinical trials of new analgesics.

Neurotherapeutics 6:749–754, 2009.

Cho H, Yang YD, Lee J, Lee B, Kim T, Jang Y, Back SK, Na HS, Harfe BD, Wang F, Raouf R, Wood JN, Oh U.

The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci 27:1015–1021, 2012.

Cholewinski A, Burgess GM, Bevan S. The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons. Neuroscience 55:1015–1023, 1993.

Chopra B, Giblett S, Little JG, Donaldson LF, Tate S, Evans RJ, Grubb BD. Cyclooxygenase-1 is a marker for a subpopulation of putative nociceptive neurons in rat dorsal root ganglia. Eur J Neurosci 12:911–920, 2000.

Chu CJ, Huang SM, De Petrocellis L, Bisogno T, Ewing SA, Miller JD, Zipkin RE, Daddario N, Appendino G, Di Marzo V, Walker JM. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J Biol Chem 278:13633–13639, 2003.

Chuang HH, Prescott ED, Kong H, Shields S, Jordt S-E, Basbaum AI, Chao MV, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns[4,5]P2-mediated inhibition. Nature 411: 957–962, 2001.

Chung MK, Lee H, Caterina MJ. Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J Biol Chem 278:32037–32046, 2003.

Cleland CL, Lim FY, Gebhart GF. Pentobarbital prevents the development of C fiber-induced hyperalgesia in the rat. Pain 57:31–43, 1994.

Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407:1011–1015, 2000.

Coderre TJ, Melzack R. Cutaneous hyperalgesia: contributions of the peripheral and central nervous systems to the increase in pain sensitivity after injury. Brain Research 404:95–106, 1987.

Colburn RW, Lubin ML, Stone DJ Jr, Wang Y, Lawrence D, D'Andrea MR, Brandt MR, Liu Y, Flores CM, Qin N.Attenuated cold sensitivity in TRPM8 null mice. Neuron 54:379–386, 2007.

Corsi MM, Ticozzi C, Netti C, Fulgenzi A, Tiengo M, Gaja G, Guidobono F, Ferrero ME. The effect of somatostatin on experimental inflammation in rats. Anesth Analg 85:1112–1115, 1997.

Crandall M, Kwash J, Yu W, White G. Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes. Pain 98:109–117, 2002.

Cui M, Nicol GD. Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons. Neuroscience 66:459–466, 1995.

Dalsgaard CJ, Jernbeck J, Stains W, Kjartansson J, Haegerstrand A, Hökfelt T, Brodin E, Cuello AC, Brown JC.

Calcitonin gene-related peptide-like immunoreactivity in nerve fibers in the human skin. Relation to fibers containing substance P-, somatostatin- and vasocactive intestinalpolypeptide-like immunoreactivity.

Histochemistry 91:35-38, 1989.

D’Amour FE, Smith DL. A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74–79, 1941.

Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA.

Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405:183–187, 2000.

Davis KD, Pope GE. Noxious cold evokes multiple sensations with distinct time courses. Pain 98:179–185, 2002.

De Petrocellis L, Harrison S, Bisogno T, Tognetto M, Brandi I, Smith GD, Creminon C, Davis JB, Geppetti P, Di Marzo V. The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase. J Neurochem 77:1660–1663, 2001.

del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours MD, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM.

TRPA1 contributes to cold hypersensitivity. J Neurosci 10:15165–15174, 2010.

Dhaka A, Viswanath V, Patapoutian A. TRP ion channels and temperature sensation. Ann Rev Neurosci 29:135–

161, 2006.

Dhaka A, Murray AN, Mathur J, Earley TJ, Petrus MJ, Patapoutian A. TRPM8 is required for cold sensation in mice. Neuron 54:371–378, 2007.

Di Marzo V, Bisogno T, De Petrocellis L. Anandamide: some like it hot. Trends Pharmacol Sci 22:346–349, 2001.

Dickenson AH, Dray A. Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br J Pharmacol 104:1045–1049, 1991.

Dirajlal S, Pauers LE, Stucky CL. Differential response properties of IB(4)-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J Neurophysiol 89:513–524, 2003.

Dirig DM, Isakson PC, Yaksh TL. Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J Pharmacol Exp Ther 285:1031–1038, 1998.

Docherty RJ, Yeats JC, Bevan S, Boddeke HW. Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats. Pflüger's Archives 431:828–837, 1996.

Docherty RJ, Yeats JC, Piper AS. Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion neurones in culture. Br J Pharmacol 121:1461–1467, 1997.

Dogrul A, Gülmez SE, Deveci MS, Gul H, Ossipov MH, Porreca F, Tulunay FC. The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. Anesth Analg 104:927–935, 2007.

Dray A, Forbes CA, Burgess GM. Ruthenium red blocks the capsaicininduced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro.

Neurosci Lett 110:52–59, 1990.

Dray A, Patel IA, Perkins MN, Rueff A. Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro. Br J Pharmacol 107:1129–1134, 1992.

Dray A. Chemical activation and sensitization of nociceptors. In: Peripheral neurons in nociception: physio-pharmacological aspects. Besson JM, Guilbaud G, Ollat H (eds.) John Libbey Eurotext, Paris, pp. 49–70, 1994.

Dux M, Sann H, Schemann M, Jancsó G. Changes in fibre populations of the rat hairy skin following selective chemodenervation by capsaicin. Cell Tissue Res 296:471–477, 1999.

Eckert WA 3rd, Julius D, Basbaum AI. Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse. Pain 126:184–197, 2006.

Eid SR. To feel or not to feel – targeting the heat sensor TRPV1 for pain management. Keystone Meeting on Neurobiology of Pain and Analgesia, Santa Fe, New Mexico, 2009.

Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, Henze DA, Kane SA, Urban MO. HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain 4:48, 2008.

Eide PK, Tjølsen A. Effects of serotonin receptor antagonists and agonists on the tail-flick response in mice involve altered tail-skin temperature. Neuropharmacol 27:889–893, 1988.

Engelhardt G, Homma D, Schlegel K, Utzmann R, Schnitzler C. Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal antiinflammatory agent with favorable gastrointestinal tolerance. Inflamm Res 44:423–433, 1995.

England S, Bevan S, Docherty RJ. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol (Lond.) 495:429–440, 1996.

El Bitar N, Pollin B, Karroum E, Pincedé I, Mouraux A, Le Bars D. Thermoregulatory vasomotor tone of the rat tail and paws in thermoneutral conditions and its impact on a behavioral model of acute pain. J Neurophysiol 112:2185–2198, 2014.

El Bitar N, Pollin B, Karroum E, Pincedé I, Le Bars D. Entanglement between thermoregulation and nociception in the rat: the case of morphine. J Neurophysiol 116:2473–2496, 2016.

Ercoli N, Lewis MN. Studies on analgesics. J Pharmacol Exp Ther 84:301–317, 1945.

Evans AR, Vasko MR, Nicol GD. The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones. J Physiol (Lond.) 516:163–178, 1999.

Everaerts W, Gees M, Alpizar YA, Farre R, Leten C, Apetrei A, Dewachter I, van Leuven F, Vennekens R, De Ridder D, Nilius B, Voets T, Talavera K. The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. Curr Biol 21:316–321, 2011.

Fajardo O, Meseguer V, Belmonte C, Viana F. TRPA1 channels mediate cold temperature sensing in mammalian vagal sensory neurons: pharmacological and genetic evidence. J Neurosci 28:7863–7875, 2008.

Farré AJ, Colombo M, Gutiérrez B. Maximum tolerated temperature in the rat tail: a broadly sensitive test of analgesic activity. Methods Find Exp Clin Pharmacol 11:303–307, 1989.

Ferrari LF, Gear RW, Levine JD. Attenuation of activity in an endogenous analgesia circuit by ongoing pain in the rat. J Neurosci 30:13699–13706, 2010.

Ferreira SH, Lorenzetti BB, Correa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol 53:39–48, 1978.

Fialip J, Porteix A, Marty H, Eschalier A, Duchêne-Marullaz P. Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice. Arch Int Pharmacodyn Ther 302:86–95, 1989.