1a.
Q: Choose the correct statements concerning the properties of the human genome!
A: Human genome is made of roughly 100 thousand genes K: F
A: The size of the haploid genome is approximately 6 billion base pairs.
K: F
A: All human cells have the same DNA content without exceptions.
K: F
A: Mitochondria contain a variant of DNA that has Uracil in place of Thymine K: F
A: Diploid genome is approximately 6 billion base pairs long K: T
A: Mitochondrial DNA is present in several copies per cell.
K: T
A: Nuclear DNA is organized in chromosomes.
K: T
A: The chemical composition of DNA is universal in the whole biosphere.
K: T
2.
Q: Choose the correct statements regarding the methods used to investigate the human genome!
A: The genome was sequenced in 1953 by Watson and Crick in the UK.
K: F
A: The sequence of the human genome can be investigated on nucleotide level by X-ray diffraction methods.
K: F
A: Sequencing the Human Genome is performed nowadays by using bacterial microreactors.
K: F
A: Sequencing of the Human genome was performed at Genopole near Paris.
K: F
A: The human genome was sequenced in a collaborative work in an international effort.
K: T
A: The draft of the human genome map was drawn by combining public and private data sets.
K: T
A: The method that is used for the novo sequencing is the shotgun sequencing.
K: T
A: The price of sequencing is decreasing rapidly by miniaturization and by eliminating bacterial work and replacing it with pure enzymatic methods.
K: T
3.
Q: Choose the correct statements regarding the regulation of transcription!
A: Euchromatin and heterochromatin is an electro microscopic artefact.
K: F
A: Transcription is regulated only by protein phosphorylation.
K: F
A: Histone methylation is a repressive mark K: F
A: DNA is transcribed by DNA polymerase.
K: F
A: DNA is transcribed by RNA polymerases.
K: T
A: Histone acetylation is an activator mark.
K: T
A: DNA methylation is usually a repressive mark K: T
A: Heterochromatin is a condensed chromatin region with no transcription and specific histone markers.
K: T
4.
Q: Choose the correct statements regarding nuclear receptors!
A: Nuclear receptors are sensors of radioactive isotopes.
K: F
A: Nuclear receptors are sitting in the membrane and act through G proteins.
K: F
A: Nuclear receptors are direct regulators of splicing.
K: F
A: Nuclear receptors can be easily detected from plasma.
K: F
A: Nuclear receptors have always a DNA binding domain.
K: T
A: Nuclear receptors have a ligand binding domain that is able to recognize various lipids.
K: T
A: Nuclear receptors are translating the lipid environment into specific genetic programs.
K: T
A: The site of action of the ligand activated nuclear receptors is in the nucleus.
K: T
