94
95 the first time. The silver-selective electrodes had outstanding selectivities exceeding any selectivities reported before and an ultratrace detection limit of 2 × 10-8 M.
Three-dimensionally ordered PEDOT(PSS) conducting polymer, loaded with the lipophilic redox mediator 1,1’-dimethylferrocene (DMFe), as large surface area solid-contact in silver ion-selective electrodes was found the be beneficial in terms of 𝐸0 reproducibility and long term stability of the electrodes.
By nanosphere lithography polymeric nanostructures of PEDOT(PSS) conducting polymer were synthesized, and the thickness of the layers was optimized using atomic force microscopy. This polymeric nanostructures can be utilized as a biorecognition layer, surface-imprinted polymer.
The main results of this thesis can be summarized in the following points:
1. I developed a novel potentiometric enzyme-linked immunosorbent assay (ELISA) for the detection of prostate specific antigen in human serum samples. The assay scheme was based on measuring an anionic product of the enzyme label with anion-exchanger based minielectrodes. [Paper I.]
2. I made the proof of principle for potentiometric detection of microfluidic paper-based bioaffinity assays by measuring silver ions directly in the wet paper matrix. The silver ions were generated from dissolution of the metallic silver layer deposited on the gold surface of the aptamer-gold nanoparticle conjugates used as biorecognition element in the human IgE assay. [Paper II.]
3. I prepared solid-contact silver-selective electrodes with outstanding selectivities exceeding any selectivities reported before, good 𝐸0 reproducibility and ultratrace detection limit. As ion-to-electron transducer layer I used polyaniline nanoparticles and for the ion-selective membrane matrix I utilized room temperature vulcanizing silicon rubber. [Paper III.]
96
4. I fabricated two- and three dimensionally ordered polymeric nanostructures of PEDOT(PSS) conducting polymer by nanosphere lithography for the first time. I optimized the thickness of the 2D patterned polymer for subsequent application in surface imprinted polymers as biorecognition element and utilized the 3D ordered PEDOT(PSS) as high surface area to-electron transducer in ion-selective electrodes. [Paper IV. and V.]
5. I found the use of 3D ordered PEDOT(PSS) conducting polymer, loaded with a lipophilic redox mediator as large surface area solid-contact in silver-selective electrodes beneficial in terms of 𝐸0 reproducibility and long term potential stability of the electrodes. [Paper IV.]
97
Declaration
I, the undersigned Júlia Szűcs hereby declare, that this doctoral dissertation is my own work, and I have only used the sources that are referred to. I have clearly indicated all parts that were taken from other sources and quoted literally or in paraphrase.
Nyilatkozat
Alulírott, Szűcs Júlia kijelentem, hogy ezt a doktori értekezést magam készítettem és abban csak a megadott forrásokat használtam fel. Minden olyan részt, amelyet szó szerint, vagy azonos tartalomban, de átfogalmazva más forrásból átvettem, egyértelműen, a forrás megadásával megjelöltem.
Budapest, 2015.09.15.
Szűcs Júlia
98
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