1. Hokin MR, Hokin LE. (1953) Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J Biol Chem, 203: 967-77.
2. Di Paolo G, De Camilli P. (2006) Phosphoinositides in cell regulation and membrane dynamics. Nature, 443: 651-7.
3. Balla T. (2013) Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev, 93: 1019-137.
4. McCartney AJ, Zhang Y, Weisman LS. (2014) Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance. Bioessays, 36: 52-64.
5. Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A.
(2009) Mammalian phosphoinositide kinases and phosphatases. Prog Lipid Res, 48:
307-43.
6. Idevall-Hagren O, De Camilli P. (2015) Detection and manipulation of phosphoinositides. Biochim Biophys Acta, 1851: 736-45.
7. Lemmon MA. (2008) Membrane recognition by phospholipid-binding domains.
Nat Rev Mol Cell Biol, 9: 99-111.
8. Nasuhoglu C, Feng S, Mao J, Yamamoto M, Yin HL, Earnest S, Barylko B, Albanesi JP, Hilgemann DW. (2002) Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal Biochem, 301: 243-54.
9. Wenk MR, Lucast L, Di Paolo G, Romanelli AJ, Suchy SF, Nussbaum RL, Cline GW, Shulman GI, McMurray W, De Camilli P. (2003) Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry. Nat Biotechnol, 21: 813-7.
10. Hammond GR, Balla T. (2015) Polyphosphoinositide binding domains: Key to inositol lipid biology. Biochim Biophys Acta, 1851: 746-58.
11. Balla T, Baukal AJ, Guillemette G, Catt KJ. (1988) Multiple pathways of inositol polyphosphate metabolism in angiotensin-stimulated adrenal glomerulosa cells.
J Biol Chem, 263: 4083-91.
107
12. Falkenburger BH, Jensen JB, Hille B. (2010) Kinetics of PIP2 metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells. J Gen Physiol, 135: 99-114.
13. Haucke V. (2005) Phosphoinositide regulation of clathrin-mediated endocytosis.
Biochem Soc Trans, 33: 1285-9.
14. Posor Y, Eichhorn-Gruenig M, Puchkov D, Schoneberg J, Ullrich A, Lampe A, Muller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noe F, Haucke V. (2013) Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature, 499: 233-7.
15. Majumder AL, Chatterjee A, Ghosh Dastidar K, Majee M. (2003) Diversification and evolution of L-myo-inositol 1-phosphate synthase. FEBS Lett, 553:
3-10.
16. Schneider S. (2015) Inositol transport proteins. FEBS Lett, 589: 1049-58.
17. Burg MB, Ferraris JD. (2008) Intracellular organic osmolytes: function and regulation. J Biol Chem, 283: 7309-13.
18. Kim YJ, Guzman-Hernandez ML, Balla T. (2011) A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranes. Dev Cell, 21: 813-24.
19. Cockcroft S, Garner K. (2011) Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action? Crit Rev Biochem Mol Biol, 46: 89-117.
20. Routt SM, Bankaitis VA. (2004) Biological functions of phosphatidylinositol transfer proteins. Biochem Cell Biol, 82: 254-62.
21. Kim YJ, Guzman-Hernandez ML, Wisniewski E, Balla T. (2015) Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence. Dev Cell, 33: 549-61.
22. Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science, 260: 88-91.
23. Stack JH, DeWald DB, Takegawa K, Emr SD. (1995) Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34
108
PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J Cell Biol, 129:
321-34.
24. Jones AT, Clague MJ. (1995) Phosphatidylinositol 3-kinase activity is required for early endosome fusion. Biochem J, 311 ( Pt 1): 31-4.
25. Patki V, Virbasius J, Lane WS, Toh BH, Shpetner HS, Corvera S. (1997) Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase.
Proc Natl Acad Sci U S A, 94: 7326-30.
26. Clague MJ, Urbe S, de Lartigue J. (2009) Phosphoinositides and the endocytic pathway. Exp Cell Res, 315: 1627-31.
27. Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H. (2000) Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J, 19: 4577-88.
28. Sarkes D, Rameh LE. (2010) A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J, 428: 375-84.
29. Schink KO, Raiborg C, Stenmark H. (2013) Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling. Bioessays, 35: 900-12.
30. Backer JM. (2008) The regulation and function of Class III PI3Ks: novel roles for Vps34. Biochem J, 410: 1-17.
31. Funderburk SF, Wang QJ, Yue Z. (2010) The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol, 20: 355-62.
32. Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E. (2014) PI3K class II alpha controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell, 28: 647-58.
33. Cao C, Laporte J, Backer JM, Wandinger-Ness A, Stein MP. (2007) Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic, 8: 1052-67.
109
34. Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger-Ness A. (2008) Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Biol Cell, 19: 3334-46.
35. Amoasii L, Hnia K, Laporte J. (2012) Myotubularin phosphoinositide phosphatases in human diseases. Curr Top Microbiol Immunol, 362: 209-33.
36. Audhya A, Emr SD. (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell, 2: 593-605.
37. Hammond GR, Schiavo G, Irvine RF. (2009) Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J, 422:
23-35.
38. Hammond GR, Machner MP, Balla T. (2014) A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi. J Cell Biol, 205: 113-26.
39. Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T.
(2008) Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell, 19: 711-21.
40. Hama H, Schnieders EA, Thorner J, Takemoto JY, DeWald DB. (1999) Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem, 274: 34294-300.
41. De Matteis MA, D'Angelo G. (2007) The role of the phosphoinositides at the Golgi complex. Biochem Soc Symp, 107-16.
42. Hammond GR, Fischer MJ, Anderson KE, Holdich J, Koteci A, Balla T, Irvine RF. (2012) PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. Science, 337: 727-30.
43. De Matteis MA, Wilson C, D'Angelo G. (2013) Phosphatidylinositol-4-phosphate: the Golgi and beyond. Bioessays, 35: 612-22.
44. Altan-Bonnet N, Balla T. (2012) Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms. Trends Biochem Sci, 37: 293-302.
45. Balla A, Balla T. (2006) Phosphatidylinositol 4-kinases: old enzymes with emerging functions. Trends Cell Biol, 16: 351-61.
110
46. Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, Luini A, Corda D, De Matteis MA. (1999) ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol, 1: 280-7.
47. Weixel KM, Blumental-Perry A, Watkins SC, Aridor M, Weisz OA. (2005) Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases. J Biol Chem, 280: 10501-8.
48. Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL. (2003) Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell, 114: 299-310.
49. Balla A, Tuymetova G, Tsiomenko A, Varnai P, Balla T. (2005) A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Mol Biol Cell, 16: 1282-95.
50. Chung J, Nakatsu F, Baskin JM, De Camilli P. (2015) Plasticity of PI4KIIIalpha interactions at the plasma membrane. EMBO Rep, 16: 312-20.
51. Bojjireddy N, Guzman-Hernandez ML, Reinhard NR, Jovic M, Balla T. (2015) EFR3s are palmitoylated plasma membrane proteins that control responsiveness to G-protein-coupled receptors. J Cell Sci, 128: 118-28.
52. Blumental-Perry A, Haney CJ, Weixel KM, Watkins SC, Weisz OA, Aridor M.
(2006) Phosphatidylinositol 4-phosphate formation at ER exit sites regulates ER export.
Dev Cell, 11: 671-82.
53. Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P. (2015) INTRACELLULAR TRANSPORT.
PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Science, 349: 428-32.
54. Sbrissa D, Ikonomov OC, Filios C, Delvecchio K, Shisheva A. (2012) Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636. Am J Physiol Cell Physiol, 303: C436-46.
55. Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. (2012) In vivo, Pikfyve generates PI(3,5)P2, which serves as both a
111
signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A, 109:
17472-7.
56. Roberts HF, Clarke JH, Letcher AJ, Irvine RF, Hinchliffe KA. (2005) Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines. FEBS Lett, 579: 2868-72.
57. Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D'Santos CS, Divecha N. (2006) Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta. Mol Cell, 23: 685-95.
58. Pendaries C, Tronchere H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B. (2006) PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J, 25: 1024-34.
59. Gupta A, Toscano S, Trivedi D, Jones DR, Mathre S, Clarke JH, Divecha N, Raghu P. (2013) Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development. Proc Natl Acad Sci U S A, 110: 5963-8.
60. Nunes JA, Guittard G. (2013) An Emerging Role for PI5P in T Cell Biology.
Front Immunol, 4: 80.
61. Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B. (2002) Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J, 21: 5069-78.
62. Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L, Grinstein S. (2007) Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol, 129: 267-83.
63. Jude JG, Spencer GJ, Huang X, Somerville TD, Jones DR, Divecha N, Somervaille TC. (2015) A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival. Oncogene, 34: 1253-62.
64. Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC. (2001) DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A, 98: 9671-6.
112
65. Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA. (2010) Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers. Proc Natl Acad Sci U S A, 107: 22231-6.
66. Bae YH, Ding Z, Das T, Wells A, Gertler F, Roy P. (2010) Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proc Natl Acad Sci U S A, 107: 21547-52.
67. Watt SA, Kimber WA, Fleming IN, Leslie NR, Downes CP, Lucocq JM. (2004) Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J, 377: 653-63.
68. Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A, Downes CP. (2003) Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J, 22:
5501-10.
69. Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T. (2010) The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Nature, 465: 497-501.
70. Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC.
(2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell, 16: 115-25.
71. Aich J, Mabalirajan U, Ahmad T, Agrawal A, Ghosh B. (2012) Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation. Nat Commun, 3: 877.
72. Ferron M, Boudiffa M, Arsenault M, Rached M, Pata M, Giroux S, Elfassihi L, Kisseleva M, Majerus PW, Rousseau F, Vacher J. (2011) Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab, 14: 466-77.
113
73. Li H, Marshall AJ. (2015) Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling. Cell Signal, 27:
1789-98.
74. Li X, Wang X, Zhang X, Zhao M, Tsang WL, Zhang Y, Yau RG, Weisman LS, Xu H. (2013) Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics. Proc Natl Acad Sci U S A, 110: 21165-70.
75. Shen J, Liu X, Yu WM, Liu J, Nibbelink MG, Guo C, Finkel T, Qu CK. (2011) A critical role of mitochondrial phosphatase Ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol, 31: 4902-16.
76. Takasuga S, Sasaki T. (2013) Phosphatidylinositol-3,5-bisphosphate:
metabolism and physiological functions. J Biochem, 154: 211-8.
77. Sbrissa D, Ikonomov OC, Fenner H, Shisheva A. (2008) ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality. J Mol Biol, 384: 766-79.
78. Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS. (2008) VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J, 27: 3221-34.
79. Yamamoto A, DeWald DB, Boronenkov IV, Anderson RA, Emr SD, Koshland D. (1995) Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Mol Biol Cell, 6: 525-39.
80. Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK. (2009) Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol, 11: 769-76.
81. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Cell, 151: 372-83.
114
82. Bolis A, Zordan P, Coviello S, Bolino A. (2007) Myotubularin-related (MTMR) phospholipid phosphatase proteins in the peripheral nervous system. Mol Neurobiol, 35:
308-16.
83. Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH.
(2009) Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet, 84: 85-8.
84. Campeau PM, Lenk GM, Lu JT, Bae Y, Burrage L, Turnpenny P, Roman Corona-Rivera J, Morandi L, Mora M, Reutter H, Vulto-van Silfhout AT, Faivre L, Haan E, Gibbs RA, Meisler MH, Lee BH. (2013) Yunis-Varon syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase. Am J Hum Genet, 92:
781-91.
85. Li S, Tiab L, Jiao X, Munier FL, Zografos L, Frueh BE, Sergeev Y, Smith J, Rubin B, Meallet MA, Forster RK, Hejtmancik JF, Schorderet DF. (2005) Mutations in PIP5K3 are associated with Francois-Neetens mouchetee fleck corneal dystrophy. Am J Hum Genet, 77: 54-63.
86. Stauffer TP, Ahn S, Meyer T. (1998) Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells. Curr Biol, 8:
343-6.
87. Varnai P, Balla T. (1998) Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J Cell Biol, 143: 501-10.
88. Hammond GR, Dove SK, Nicol A, Pinxteren JA, Zicha D, Schiavo G. (2006) Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells. J Cell Sci, 119: 2084-94.
89. Watt SA, Kular G, Fleming IN, Downes CP, Lucocq JM. (2002) Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1. Biochem J, 363: 657-66.
90. Lingwood D, Simons K. (2010) Lipid rafts as a membrane-organizing principle.
Science, 327: 46-50.
115
91. Maleth J, Choi S, Muallem S, Ahuja M. (2014) Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating. Nat Commun, 5: 5843.
92. Choi S, Thapa N, Tan X, Hedman AC, Anderson RA. (2015) PIP kinases define PI4,5P(2)signaling specificity by association with effectors. Biochim Biophys Acta, 1851: 711-23.
93. Doughman RL, Firestone AJ, Anderson RA. (2003) Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. J Membr Biol, 194: 77-89.
94. van den Bout I, Divecha N. (2009) PIP5K-driven PtdIns(4,5)P2 synthesis:
regulation and cellular functions. J Cell Sci, 122: 3837-50.
95. Nakanishi S, Catt KJ, Balla T. (1995) A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids. Proc Natl Acad Sci U S A, 92: 5317-21.
96. Dickson EJ, Jensen JB, Hille B. (2014) Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current. Proc Natl Acad Sci U S A, 111: E2281-90.
97. Ling Y, Stefan CJ, Macgurn JA, Audhya A, Emr SD. (2012) The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P(2) synthesis.
EMBO J, 31: 2882-94.
98. Berridge MJ, Irvine RF. (1984) Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature, 312: 315-21.
99. Connolly TM, Bross TE, Majerus PW. (1985) Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate. J Biol Chem, 260: 7868-74.
100. Hsu F, Mao Y. (2015) The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis. Biochim Biophys Acta, 1851: 698-710.
101. McPherson PS, Garcia EP, Slepnev VI, David C, Zhang X, Grabs D, Sossin WS, Bauerfeind R, Nemoto Y, De Camilli P. (1996) A presynaptic inositol-5-phosphatase.
Nature, 379: 353-7.
102. Niggli V, Adunyah ES, Carafoli E. (1981) Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPase. J Biol Chem, 256: 8588-92.
116
103. Rohacs T. (2014) Phosphoinositide regulation of TRP channels. Handb Exp Pharmacol, 223: 1143-76.
104. Korzeniowski MK, Popovic MA, Szentpetery Z, Varnai P, Stojilkovic SS, Balla T. (2009) Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. J Biol Chem, 284: 21027-35.
105. Hansen SB, Tao X, MacKinnon R. (2011) Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature, 477: 495-8.
106. Zhang H, He C, Yan X, Mirshahi T, Logothetis DE. (1999) Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nat Cell Biol, 1:
183-8.
107. Tsujita K, Itoh T. (2015) Phosphoinositides in the regulation of actin cortex and cell migration. Biochim Biophys Acta, 1851: 824-31.
108. Levin R, Grinstein S, Schlam D. (2015) Phosphoinositides in phagocytosis and macropinocytosis. Biochim Biophys Acta, 1851: 805-23.
109. Martin TF. (2015) PI(4,5)P(2)-binding effector proteins for vesicle exocytosis.
Biochim Biophys Acta, 1851: 785-93.
110. Posor Y, Eichhorn-Grunig M, Haucke V. (2015) Phosphoinositides in endocytosis. Biochim Biophys Acta, 1851: 794-804.
111. Toth DJ, Toth JT, Gulyas G, Balla A, Balla T, Hunyady L, Varnai P. (2012) Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor. J Cell Sci, 125: 2185-97.
112. Narkis G, Ofir R, Landau D, Manor E, Volokita M, Hershkowitz R, Elbedour K, Birk OS. (2007) Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes PIPKI gamma of the phophatidylinsitol pathway. Am J Hum Genet, 81: 530-9.
113. Singhal RL, Prajda N, Yeh YA, Weber G. (1994) 1-Phosphatidylinositol 4-phosphate 5-kinase (EC 2.7.1.68): a proliferation- and malignancy-linked signal transduction enzyme. Cancer Res, 54: 5574-8.
114. Pirruccello M, De Camilli P. (2012) Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL. Trends Biochem Sci, 37: 134-43.
117
115. Hoopes RR, Jr., Shrimpton AE, Knohl SJ, Hueber P, Hoppe B, Matyus J, Simckes A, Tasic V, Toenshoff B, Suchy SF, Nussbaum RL, Scheinman SJ. (2005) Dent Disease with mutations in OCRL1. Am J Hum Genet, 76: 260-7.
116. Toker A, Cantley LC. (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature, 387: 673-6.
117. Yip SC, Eddy RJ, Branch AM, Pang H, Wu H, Yan Y, Drees BE, Neilsen PO, Condeelis J, Backer JM. (2008) Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. Biochem J, 411: 441-8.
118. Oikawa T, Yamaguchi H, Itoh T, Kato M, Ijuin T, Yamazaki D, Suetsugu S, Takenawa T. (2004) PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol, 6: 420-6.
119. Kok K, Geering B, Vanhaesebroeck B. (2009) Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci, 34: 115-27.
120. Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA. (1997) Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem, 272: 17756-61.
121. Blero D, Payrastre B, Schurmans S, Erneux C. (2007) Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch, 455: 31-44.
122. Bayascas JR, Wullschleger S, Sakamoto K, Garcia-Martinez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR. (2008) Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol, 28: 3258-72.
123. Salamon RS, Backer JM. (2013) Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays, 35: 602-11.
124. Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J.
(1998) Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J, 17: 414-22.
125. Nakanishi H, Brewer KA, Exton JH. (1993) Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem, 268: 13-6.
118
126. Berridge, M.J.; Cell Signalling Biology Module 2; Portland Press Limited, London (2014) p62-64.
127. Sasaki T, Sasaki J, Sakai T, Takasuga S, Suzuki A. (2007) The physiology of phosphoinositides. Biol Pharm Bull, 30: 1599-604.
128. Eng C. (2003) PTEN: one gene, many syndromes. Hum Mutat, 22: 183-98.
129. Manna P, Jain SK. (2015) Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes. Cell Physiol Biochem, 35: 1253-75.
130. Stahelin RV, Scott JL, Frick CT. (2014) Cellular and molecular interactions of phosphoinositides and peripheral proteins. Chem Phys Lipids, 182: 3-18.
131. Harlan JE, Hajduk PJ, Yoon HS, Fesik SW. (1994) Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature, 371: 168-70.
132. Kutateladze TG. (2010) Translation of the phosphoinositide code by PI effectors. Nat Chem Biol, 6: 507-13.
133. Yu JW, Lemmon MA. (2001) All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem, 276: 44179-84.
134. Yu JW, Mendrola JM, Audhya A, Singh S, Keleti D, DeWald DB, Murray D, Emr SD, Lemmon MA. (2004) Genome-wide analysis of membrane targeting by S.
cerevisiae pleckstrin homology domains. Mol Cell, 13: 677-88.
135. Manna D, Albanese A, Park WS, Cho W. (2007) Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. J Biol Chem, 282: 32093-105.
136. Szentpetery Z, Balla A, Kim YJ, Lemmon MA, Balla T. (2009) Live cell imaging with protein domains capable of recognizing phosphatidylinositol 4,5-bisphosphate; a comparative study. BMC Cell Biol, 10: 67.
137. Klein DE, Lee A, Frank DW, Marks MS, Lemmon MA. (1998) The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. J Biol Chem, 273: 27725-33.
138. Carlton JG, Cullen PJ. (2005) Coincidence detection in phosphoinositide signaling. Trends Cell Biol, 15: 540-7.
119
139. van Weering JR, Sessions RB, Traer CJ, Kloer DP, Bhatia VK, Stamou D, Carlsson SR, Hurley JH, Cullen PJ. (2012) Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J, 31: 4466-80.
140. Levine TP, Munro S. (2002) Targeting of Golgi-specific pleckstrin homology
140. Levine TP, Munro S. (2002) Targeting of Golgi-specific pleckstrin homology