• Nem Talált Eredményt

1. Abe, K. és M. Takeichi (2008). "EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt." Proc Natl Acad Sci U S A 105(1): 13-19.

2. Acloque, H., M. S. Adams, K. Fishwick, M. Bronner-Fraser és M. A. Nieto (2009). "Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease." J Clin Invest 119(6): 1438-1449.

3. Anderberg, C., S. I. Cunha, Z. Zhai, E. Cortez, E. Pardali, J. R. Johnson, M.

Franco, M. Paez-Ribes, R. Cordiner, J. Fuxe, B. R. Johansson, M. J. Goumans, O.

Casanovas, P. ten Dijke, H. M. Arthur és K. Pietras (2013). "Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination." J Exp Med 210(3): 563-579.

4. Andrei V. Bakin, C. R., Anne K. Tomlinson, Carlos L. Arteaga (2002). "p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration." J Cell Sci(115): 3193-3206.

5. Arnoux, V., M. Nassour, A. L'Helgoualc'h, R. A. Hipskind és P. Savagner (2008).

"Erk5 controls Slug expression and keratinocyte activation during wound healing." Mol Biol Cell 19(11): 4738-4749.

6. Asparuhova, M. B., J. Ferralli, M. Chiquet és R. Chiquet-Ehrismann (2011). "The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress." FASEB J 25(10): 3477-3488.

7. Asparuhova, M. B., C. Secondini, C. Ruegg és R. Chiquet-Ehrismann (2015).

"Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling." Mol Oncol 9(8): 1510-1527.

8. Baarlink, C., H. Wang és R. Grosse (2013). "Nuclear actin network assembly by formins regulates the SRF coactivator MAL." Science 340(6134): 864-867.

9. Bai, F., H. L. Chan, A. Scott, M. D. Smith, C. Fan, J. I. Herschkowitz, C. M.

Perou, A. S. Livingstone, D. J. Robbins, A. J. Capobianco és X. H. Pei (2014). "BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development." Cancer Res 74(21): 6161-6172.

86

10. Barnholtz-Sloan, J. S., A. E. Sloan, F. G. Davis, F. D. Vigneau, P. Lai és R. E.

Sawaya (2004). "Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System." J Clin Oncol 22(14):

2865-2872.

11. Barthel, S. R., D. L. Hays, E. M. Yazawa, M. Opperman, K. C. Walley, L.

Nimrichter, M. M. Burdick, B. M. Gillard, M. T. Moser, K. Pantel, B. A. Foster, K. J.

Pienta és C. J. Dimitroff (2013). "Definition of molecular determinants of prostate cancer cell bone extravasation." Cancer Res 73(2): 942-952.

12. Batlle, E., E. Sancho, C. Franci, D. Dominguez, M. Monfar, J. Baulida és A.

Garcia De Herreros (2000). "The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells." Nat Cell Biol 2(2): 84-89.

13. Baulida, J. (2017). "Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts." Mol Oncol 11(7): 847-859.

14. Beumer, J. és H. Clevers (2016). "Regulation and plasticity of intestinal stem cells during homeostasis and regeneration." Development 143(20): 3639-3649.

15. Bhowmick, N. A., M. Ghiassi, A. Bakin, M. Aakre, C. A. Lundquist, M. E. Engel, C. L. Arteaga és H. L. Moses (2001). "Transforming Growth Factor- 1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism."

Molecular Biology of the Cell 12(1): 27-36.

16. Blanpain, C. és E. Fuchs (2014). "Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration." Science 344(6189): 1242281.

17. Bodor, C., J. P. Nagy, B. Vegh, A. Nemeth, A. Jenei, S. MirzaHosseini, A. Sebe és L. Rosivall (2012). "Angiotensin II increases the permeability and PV-1 expression of endothelial cells." Am J Physiol Cell Physiol 302(1): C267-276.

18. Boutet, A., C. A. De Frutos, P. H. Maxwell, M. J. Mayol, J. Romero és M. A.

Nieto (2006). "Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney." EMBO J 25(23): 5603-5613.

19. Brabletz, T., A. Jung, S. Reu, M. Porzner, F. Hlubek, L. A. Kunz-Schughart, R.

Knuechel és T. Kirchner (2001). "Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment." Proc Natl Acad Sci U S A 98(18): 10356-10361.

87

20. Brandt, D. T., C. Baarlink, T. M. Kitzing, E. Kremmer, J. Ivaska, P. Nollau és R.

Grosse (2009). "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin." Nat Cell Biol 11(5): 557-568.

21. Brauchle, M., Z. Yao, R. Arora, S. Thigale, I. Clay, B. Inverardi, J. Fletcher, P.

Taslimi, M. G. Acker, B. Gerrits, J. Voshol, A. Bauer, D. Schubeler, T. Bouwmeester és H. Ruffner (2013). "Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation." PLoS One 8(4): e60549.

22. Bravi, L., N. Rudini, R. Cuttano, C. Giampietro, L. Maddaluno, L. Ferrarini, R.

H. Adams, M. Corada, G. Boulday, E. Tournier-Lasserve, E. Dejana és M. G.

Lampugnani (2015). "Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice." Proc Natl Acad Sci U S A 112(27): 8421-8426.

23. Brown, P. D., L. M. Wakefield, A. D. Levinson és M. B. Sporn (1990).

"Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3." Growth Factors 3(1): 35-43.

24. Buczacki, S. J., H. I. Zecchini, A. M. Nicholson, R. Russell, L. Vermeulen, R.

Kemp és D. J. Winton (2013). "Intestinal label-retaining cells are secretory precursors expressing Lgr5." Nature 495(7439): 65-69.

25. Burns, K. D. és R. C. Harris (1995). "Signaling and growth responses of LLC-PK1/Cl4 cells transfected with the rabbit AT1 ANG II receptor." Am J Physiol 268(4 Pt 1): C925-935.

26. Burns, W. C., S. M. Twigg, J. M. Forbes, J. Pete, C. Tikellis, V. Thallas-Bonke, M. C. Thomas, M. E. Cooper és P. Kantharidis (2006). "Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease." J Am Soc Nephrol 17(9): 2484-2494.

27. Busche, S., A. Descot, S. Julien, H. Genth és G. Posern (2008). "Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling." J Cell Sci 121(Pt 7): 1025-1035.

28. Cain, R. J., B. Vanhaesebroeck és A. J. Ridley (2010). "The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1." J Cell Biol 188(6):

863-876.

88

29. Calon, A., D. V. Tauriello és E. Batlle (2014). "TGF-beta in CAF-mediated tumor growth and metastasis." Semin Cancer Biol 25: 15-22.

30. Cao, X. L., X. M. Hu, J. Q. Hu és W. X. Zheng (2011). "Myocardin-related transcription factor-A promoting neuronal survival against apoptosis induced by hypoxia/ischemia." Brain Res 1385: 263-274.

31. Caramel, J., E. Papadogeorgakis, L. Hill, G. J. Browne, G. Richard, A. Wierinckx, G. Saldanha, J. Osborne, P. Hutchinson, G. Tse, J. Lachuer, A. Puisieux, J. H. Pringle, S.

Ansieau és E. Tulchinsky (2013). "A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma." Cancer Cell 24(4): 466-480.

32. Cen, B., A. Selvaraj, R. C. Burgess, J. K. Hitzler, Z. Ma, S. W. Morris és R.

Prywes (2003). "Megakaryoblastic Leukemia 1, a Potent Transcriptional Coactivator for Serum Response Factor (SRF), Is Required for Serum Induction of SRF Target Genes."

Molecular and Cellular Biology 23(18): 6597-6608.

33. Cenik, B. K., N. Liu, B. Chen, S. Bezprozvannaya, E. N. Olson és R. Bassel-Duby (2016). "Myocardin-related transcription factors are required for skeletal muscle development." Development 143(15): 2853-2861.

34. Chang, A. C., Y. Fu, V. C. Garside, K. Niessen, L. Chang, M. Fuller, A. Setiadi, J. Smrz, A. Kyle, A. Minchinton, M. Marra, P. A. Hoodless és A. Karsan (2011). "Notch initiates the endothelial-to-mesenchymal transition in the atrioventricular canal through autocrine activation of soluble guanylyl cyclase." Dev Cell 21(2): 288-300.

35. Charbonney, E., P. Speight, A. Masszi, H. Nakano és A. Kapus (2011). "beta-catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition." Mol Biol Cell 22(23): 4472-4485.

36. Chen, L. J., H. Ye, Q. Zhang, F. Z. Li, L. J. Song, J. Yang, Q. Mu, S. S. Rao, P.

C. Cai, F. Xiang, J. C. Zhang, Y. Su, J. B. Xin és W. L. Ma (2015). "Bleomycin induced epithelial-mesenchymal transition (EMT) in pleural mesothelial cells." Toxicol Appl Pharmacol 283(2): 75-82.

37. Chen, P. Y., L. Qin, N. Baeyens, G. Li, T. Afolabi, M. Budatha, G. Tellides, M.

A. Schwartz és M. Simons (2015). "Endothelial-to-mesenchymal transition drives atherosclerosis progression." J Clin Invest 125(12): 4514-4528.

89

38. Chen, X., W. Hu, B. Xie, H. Gao, C. Xu és J. Chen (2014). "Downregulation of SCAI enhances glioma cell invasion and stem cell like phenotype by activating Wnt/beta-catenin signaling." Biochem Biophys Res Commun 448(2): 206-211.

39. Chen, X. L., J. O. Nam, C. Jean, C. Lawson, C. T. Walsh, E. Goka, S. T. Lim, A.

Tomar, I. Tancioni, S. Uryu, J. L. Guan, L. M. Acevedo, S. M. Weis, D. A. Cheresh és D. D. Schlaepfer (2012). "VEGF-induced vascular permeability is mediated by FAK."

Dev Cell 22(1): 146-157.

40. Choi, S. H., Z. Y. Hong, J. K. Nam, H. J. Lee, J. Jang, R. J. Yoo, Y. J. Lee, C. Y.

Lee, K. H. Kim, S. Park, Y. H. Ji, Y. S. Lee, J. Cho és Y. J. Lee (2015). "A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis." Clin Cancer Res 21(16): 3716-3726.

41. Chrobak, I., S. Lenna, L. Stawski és M. Trojanowska (2013). "Interferon-gamma promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) beta2." J Cell Physiol 228(8):

1774-1783.

42. Cipriani, P., P. Di Benedetto, P. Ruscitti, D. Capece, F. Zazzeroni, V. Liakouli, I.

Pantano, O. Berardicurti, F. Carubbi, G. Pecetti, S. Turricchia, E. Alesse, M. Iglarz és R.

Giacomelli (2015). "The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-beta and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist." J Rheumatol 42(10): 1808-1816.

43. Collard, L., G. Herledan, A. Pincini, A. Guerci, V. Randrianarison-Huetz és A.

Sotiropoulos (2014). "Nuclear actin and myocardin-related transcription factors control disuse muscle atrophy through regulation of Srf activity." J Cell Sci 127(Pt 24): 5157-5163.

44. Combs, M. D. és K. E. Yutzey (2009). "Heart valve development: regulatory networks in development and disease." Circ Res 105(5): 408-421.

45. Compton, L. A., D. A. Potash, N. A. Mundell és J. V. Barnett (2006).

"Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells." Dev Dyn 235(1): 82-93.

46. Copeland, J. W. és R. Treisman (2002). "The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization." Mol Biol Cell 13(11): 4088-4099.

90

47. Costello, P., M. Sargent, D. Maurice, C. Esnault, K. Foster, F. Anjos-Afonso és R. Treisman (2015). "MRTF-SRF signaling is required for seeding of HSC/Ps in bone marrow during development." Blood 125(8): 1244-1255.

48. Crider, B. J., G. M. Risinger, Jr., C. J. Haaksma, E. W. Howard és J. J. Tomasek (2011). "Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation." J Invest Dermatol 131(12):

2378-2385.

49. Dasgupta, S., M. Bhattacharya-Chatterjee, B. W. O'Malley, Jr. és S. K. Chatterjee (2006). "Tumor metastasis in an orthotopic murine model of head and neck cancer:

possible role of TGF-beta 1 secreted by the tumor cells." J Cell Biochem 97(5): 1036-1051.

50. De Chiara, L. és J. Crean (2016). "Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney." J Clin Med 5(1).

51. De Craene, B. és G. Berx (2013). "Regulatory networks defining EMT during cancer initiation and progression." Nat Rev Cancer 13(2): 97-110.

52. De Wever, O., Q. D. Nguyen, L. Van Hoorde, M. Bracke, E. Bruyneel, C. Gespach és M. Mareel (2004). "Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac." FASEB J 18(9): 1016-1018.

53. Dejana, E., F. Orsenigo és M. G. Lampugnani (2008). "The role of adherens junctions and VE-cadherin in the control of vascular permeability." J Cell Sci 121(Pt 13):

2115-2122.

54. Denecker, G., N. Vandamme, O. Akay, D. Koludrovic, J. Taminau, K. Lemeire, A. Gheldof, B. De Craene, M. Van Gele, L. Brochez, G. M. Udupi, M. Rafferty, B. Balint, W. M. Gallagher, G. Ghanem, D. Huylebroeck, J. Haigh, J. van den Oord, L. Larue, I.

Davidson, J. C. Marine és G. Berx (2014). "Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression." Cell Death Differ 21(8): 1250-1261.

55. Descot, A., M. Rex-Haffner, G. Courtois, D. Bluteau, A. Menssen, T. Mercher, O. A. Bernard, R. Treisman és G. Posern (2008). "OTT-MAL is a deregulated activator of serum response factor-dependent gene expression." Mol Cell Biol 28(20): 6171-6181.

91

56. Dettman, R. W., W. Denetclaw, Jr., C. P. Ordahl és J. Bristow (1998). "Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart." Dev Biol 193(2): 169-181.

57. Donati, G. és F. M. Watt (2015). "Stem cell heterogeneity and plasticity in epithelia." Cell Stem Cell 16(5): 465-476.

58. Draheim, K. M., O. S. Fisher, T. J. Boggon és D. A. Calderwood (2014). "Cerebral cavernous malformation proteins at a glance." J Cell Sci 127(Pt 4): 701-707.

59. Drees, F., S. Pokutta, S. Yamada, W. J. Nelson és W. I. Weis (2005). "Alpha-catenin is a molecular switch that binds E-cadherin-beta-"Alpha-catenin and regulates actin-filament assembly." Cell 123(5): 903-915.

60. Du, K. L., M. Chen, J. Li, J. J. Lepore, P. Mericko és M. S. Parmacek (2004).

"Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells." J Biol Chem 279(17): 17578-17586.

61. Dudley, A. C. (2012). "Tumor endothelial cells." Cold Spring Harb Perspect Med 2(3): a006536.

62. Edlund, S., M. Landstrom, C. H. Heldin és P. Aspenstrom (2002). "Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA." Mol Biol Cell 13(3): 902-914.

63. Eisenberg, L. M. és R. R. Markwald (1995). "Molecular regulation of atrioventricular valvuloseptal morphogenesis." Circ Res 77(1): 1-6.

64. Engel, M. E., M. A. McDonnell, B. K. Law és H. L. Moses (1999).

"Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription." J Biol Chem 274(52): 37413-37420.

65. Evelyn, C. R., S. M. Wade, Q. Wang, M. Wu, J. A. Iniguez-Lluhi, S. D. Merajver és R. R. Neubig (2007). "CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling." Mol Cancer Ther 6(8): 2249-2260.

66. Fan, B., Y. Malato, D. F. Calvisi, S. Naqvi, N. Razumilava, S. Ribback, G. J.

Gores, F. Dombrowski, M. Evert, X. Chen és H. Willenbring (2012).

"Cholangiocarcinomas can originate from hepatocytes in mice." J Clin Invest 122(8):

2911-2915.

92

67. Fan JM, H. X., Ng YY, Nikolic-Paterson DJ, Mu W, Atkins RC, Lan HY. (2001).

" Interleukin-1 induces tubular epithelial-myofibroblast transdifferentiation through a transforming growth factor-beta1-dependent mechanism in vitro." Am J Kidney Dis(37):

820-831.

68. Fan, L., A. Sebe, Z. Peterfi, A. Masszi, A. C. Thirone, O. D. Rotstein, H. Nakano, C. A. McCulloch, K. Szaszi, I. Mucsi és A. Kapus (2007). "Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway." Mol Biol Cell 18(3): 1083-1097.

69. Fazakas, C., I. Wilhelm, P. Nagyoszi, A. E. Farkas, J. Hasko, J. Molnar, H. Bauer, H. C. Bauer, F. Ayaydin, N. T. Dung, L. Siklos és I. A. Krizbai (2011). "Transmigration of melanoma cells through the blood-brain barrier: role of endothelial tight junctions and melanoma-released serine proteases." PLoS One 6(6): e20758.

70. Fintha, A., A. Gasparics, L. Fang, Z. Erdei, P. Hamar, M. M. Mozes, G. Kokeny, L. Rosivall és A. Sebe (2013). "Characterization and Role of SCAI during Renal Fibrosis and Epithelial-to-Mesenchymal Transition." Am J Pathol 182(2): 388-400.

71. Fogo, A. B. (2007). "Mechanisms of progression of chronic kidney disease."

"Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats." Neurochem Int 60(3): 327-333.

74. Gabbiani, G., Y. Kapanci, P. Barazzone és W. W. Franke (1981).

"Immunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologist." Am J Pathol 104(3): 206-216.

75. Garat, C., V. Van Putten, Z. A. Refaat, C. Dessev, S. Y. Han és R. A. Nemenoff (2000). "Induction of smooth muscle alpha-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen-activated protein kinase." J Biol Chem 275(29): 22537-22543.

76. Gasperini, P., G. Espigol-Frigole, P. J. McCormick, O. Salvucci, D. Maric, T. S.

Uldrick, M. N. Polizzotto, R. Yarchoan és G. Tosato (2012). "Kaposi sarcoma herpesvirus

93

promotes endothelial-to-mesenchymal transition through Notch-dependent signaling."

Cancer Res 72(5): 1157-1169.

77. Gilles, L., D. Bluteau, S. Boukour, Y. Chang, Y. Zhang, T. Robert, P. Dessen, N.

Debili, O. A. Bernard, W. Vainchenker és H. Raslova (2009). "MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9." Blood 114(19): 4221-4232.

78. Gingery, A., E. W. Bradley, L. Pederson, M. Ruan, N. J. Horwood és M. J. Oursler (2008). "TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival." Exp Cell Res 314(15): 2725-2738.

79. Gomez, E. W., Q. K. Chen, N. Gjorevski és C. M. Nelson (2010). "Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction." J Cell Biochem 110(1): 44-51.

80. Grabundzija, I., J. Wang, A. Sebe, Z. Erdei, R. Kajdi, A. Devaraj, D. Steinemann, K. Szuhai, U. Stein, T. Cantz, A. Schambach, C. Baum, Z. Izsvak, B. Sarkadi és Z. Ivics (2013). "Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells." Nucleic Acids Res 41(3): 1829-1847.

81. Grande, M. T. és J. M. Lopez-Novoa (2009). "Fibroblast activation and myofibroblast generation in obstructive nephropathy." Nat Rev Nephrol 5(6): 319-328.

82. Grande, M. T., B. Sanchez-Laorden, C. Lopez-Blau, C. A. De Frutos, A. Boutet, M. Arevalo, R. G. Rowe, S. J. Weiss, J. M. Lopez-Novoa és M. A. Nieto (2015). "Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease." Nat Med 21(9): 989-997.

83. Haak, A. J., K. M. Appleton, E. M. Lisabeth, S. A. Misek, Y. Ji, S. M. Wade, J.

L. Bell, C. E. Rockwell, M. Airik, M. A. Krook, S. D. Larsen, M. Verhaegen, E. R. Lawlor és R. R. Neubig (2017). "Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma." Mol Cancer Ther 16(1): 193-204.

84. Haak, A. J., P. S. Tsou, M. A. Amin, J. H. Ruth, P. Campbell, D. A. Fox, D.

Khanna, S. D. Larsen és R. R. Neubig (2014). "Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response

factor-94

regulated gene transcription prevent fibrosis in a murine model of skin injury." J Pharmacol Exp Ther 349(3): 480-486.

85. Hamar, P., P. Liptak, U. Heemann és B. Ivanyi (2005). "Ultrastructural analysis of the Fisher to Lewis rat model of chronic allograft nephropathy." Transpl Int 18(7): 863-870.

86. Hamar, P., S. Liu, O. Viklicky, A. Szabo, V. Muller és U. Heemann (2000).

"Cyclosporine A and azathioprine are equipotent in chronic kidney allograft rejection."

Transplantation 69(7): 1290-1295.

87. Hansen, R. K., A. Mund, S. L. Poulsen, M. Sandoval, K. Klement, K. Tsouroula, M. A. Tollenaere, M. Raschle, R. Soria, S. Offermanns, T. Worzfeld, R. Grosse, D. T.

Brandt, B. Rozell, M. Mann, F. Cole, E. Soutoglou, A. A. Goodarzi, J. A. Daniel, N.

Mailand és S. Bekker-Jensen (2016). "SCAI promotes DNA double-strand break repair in distinct chromosomal contexts." Nat Cell Biol.

88. Hashimoto, N., S. H. Phan, K. Imaizumi, M. Matsuo, H. Nakashima, T. Kawabe, K. Shimokata és Y. Hasegawa (2010). "Endothelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis." Am J Respir Cell Mol Biol 43(2): 161-172.

89. Hay, E. (1968). "Organization and fine structure of epithelium and mesenchyme in the developing chick embryo." In Epithelial–Mesenchymal Interactions, R Fleischmajer and R.E. Billingham (eds) Baltimore, MD, USA: Williams & Wilkins Co:

pp 31–55. .

90. Hermann, M. R., M. Jakobson, G. P. Colo, E. Rognoni, M. Jakobson, C. Kupatt, G. Posern és R. Fassler (2016). "Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion." J Cell Sci 129(7): 1391-1403.

91. Heyder, C., E. Gloria-Maercker, F. Entschladen, W. Hatzmann, B. Niggemann, K. S. Zanker és T. Dittmar (2002). "Realtime visualization of tumor cell/endothelial cell interactions during transmigration across the endothelial barrier." J Cancer Res Clin Oncol 128(10): 533-538.

92. Hill, N. R., S. T. Fatoba, J. L. Oke, J. A. Hirst, C. A. O'Callaghan, D. S. Lasserson és F. D. Hobbs (2016). "Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis." PLoS One 11(7): e0158765.

95

93. Hinkel, R., T. Trenkwalder, B. Petersen, W. Husada, F. Gesenhues, S. Lee, E.

Hannappel, I. Bock-Marquette, D. Theisen, L. Leitner, P. Boekstegers, C. Cierniewski, O. J. Muller, F. le Noble, R. H. Adams, C. Weinl, A. Nordheim, B. Reichart, C. Weber, E. Olson, G. Posern, E. Deindl, H. Niemann és C. Kupatt (2014). "MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2." Nat Commun 5: 3970.

94. Hinson, J. S., M. D. Medlin, J. M. Taylor és C. P. Mack (2008). "Regulation of myocardin factor protein stability by the LIM-only protein FHL2." Am J Physiol Heart Circ Physiol 295(3): H1067-H1075.

95. Hinz, B. (2010). "The myofibroblast: paradigm for a mechanically active cell." J Biomech 43(1): 146-155.

96. Hinz, B., S. H. Phan, V. J. Thannickal, M. Prunotto, A. Desmouliere, J. Varga, O.

De Wever, M. Mareel és G. Gabbiani (2012). "Recent developments in myofibroblast biology: paradigms for connective tissue remodeling." Am J Pathol 180(4): 1340-1355.

97. Hiratsuka, S., S. Goel, W. S. Kamoun, Y. Maru, D. Fukumura, D. G. Duda és R.

K. Jain (2011). "Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation." Proc Natl Acad Sci U S A 108(9):

3725-3730.

98. Hiratsuka, S., K. Nakamura, S. Iwai, M. Murakami, T. Itoh, H. Kijima, J. M.

Shipley, R. M. Senior és M. Shibuya (2002). "MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis." Cancer Cell 2(4): 289-300.

99. Honn, K. V., D. G. Tang, I. M. Grossi, C. Renaud, Z. M. Duniec, C. R. Johnson és C. A. Diglio (1994). "Enhanced endothelial cell retraction mediated by 12(S)-HETE:

a proposed mechanism for the role of platelets in tumor cell metastasis." Exp Cell Res 210(1): 1-9.

100. Hu, B., Z. Wu és S. H. Phan (2003). "Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression." Am J Respir Cell Mol Biol 29(3 Pt 1): 397-404.

101. Hu, Q., C. Guo, Y. Li, B. J. Aronow és J. Zhang (2011). "LMO7 mediates cell-specific activation of the Rho-myocardin-related transcription factor-serum response

96

factor pathway and plays an important role in breast cancer cell migration." Mol Cell Biol 31(16): 3223-3240.

102. Huang, Y., N. Song, Y. Ding, S. Yuan, X. Li, H. Cai, H. Shi és Y. Luo (2009).

"Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis." Cancer Res 69(19): 7529-7537.

103. Hwang, W. L., J. K. Jiang, S. H. Yang, T. S. Huang, H. Y. Lan, H. W. Teng, C.

Y. Yang, Y. P. Tsai, C. H. Lin, H. W. Wang és M. H. Yang (2014). "MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells." Nat Cell Biol 16(3): 268-280.

104. Ishibe, S. és L. G. Cantley (2008). "Epithelial-mesenchymal-epithelial cycling in kidney repair." Curr Opin Nephrol Hypertens 17(4): 379-385.

105. Ishikawa, M., N. Nishijima, J. Shiota, H. Sakagami, K. Tsuchida, M. Mizukoshi, M. Fukuchi, M. Tsuda és A. Tabuchi (2010). "Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons." J Biol Chem 285(43): 32734-32743.

106. Isobe, S. Y., K. Nagao, N. Nozaki, H. Kimura és C. Obuse (2017). "Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair." Cell Rep 20(2): 297-307.

107. Ito, M., Y. Liu, Z. Yang, J. Nguyen, F. Liang, R. J. Morris és G. Cotsarelis (2005).

"Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis." Nat Med 11(12): 1351-1354.

108. Ito, M., Z. Yang, T. Andl, C. Cui, N. Kim, S. E. Millar és G. Cotsarelis (2007).

"Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding."

Nature 447(7142): 316-320.

109. Iwano, M., D. Plieth, T. M. Danoff, C. Xue, H. Okada és E. G. Neilson (2002).

"Evidence that fibroblasts derive from epithelium during tissue fibrosis." Journal of Clinical Investigation 110(3): 341-350.

110. Jean, C., X. L. Chen, J. O. Nam, I. Tancioni, S. Uryu, C. Lawson, K. K. Ward, C.

T. Walsh, N. L. Miller, M. Ghassemian, P. Turowski, E. Dejana, S. Weis, D. A. Cheresh és D. D. Schlaepfer (2014). "Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function." J Cell Biol 204(2): 247-263.

97

111. Jemal, A., T. Murray, E. Ward, A. Samuels, R. C. Tiwari, A. Ghafoor, E. J. Feuer és M. J. Thun (2005). "Cancer Statistics, 2005." CA: A Cancer Journal for Clinicians 55(1): 10-30.

112. Kao, J., K. Salari, M. Bocanegra, Y. L. Choi, L. Girard, J. Gandhi, K. A. Kwei, T.

Hernandez-Boussard, P. Wang, A. F. Gazdar, J. D. Minna és J. R. Pollack (2009).

"Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery." PLoS One 4(7): e6146.

113. Kargozaran, H., S. Y. Yuan, J. W. Breslin, K. D. Watson, N. Gaudreault, A. Breen és M. H. Wu (2007). "A role for endothelial-derived matrix metalloproteinase-2 in breast cancer cell transmigration across the endothelial-basement membrane barrier." Clin Exp Metastasis 24(7): 495-502.

114. Kato, T., A. Enomoto, T. Watanabe, H. Haga, S. Ishida, Y. Kondo, K. Furukawa, T. Urano, S. Mii, L. Weng, M. Ishida-Takagishi, M. Asai, N. Asai, K. Kaibuchi, Y.

Murakumo és M. Takahashi (2014). "TRIM27/MRTF-B-dependent integrin beta1 expression defines leading cells in cancer cell collectives." Cell Rep 7(4): 1156-1167.

115. Kavsak, P., R. K. Rasmussen, C. G. Causing, S. Bonni, H. Zhu, G. H. Thomsen és J. L. Wrana (2000). "Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation." Molecular Cell 6(6): 1365-1375.

116. Khanna, P., T. Yunkunis, H. S. Muddana, H. H. Peng, A. August és C. Dong (2010). "p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly." Am J Physiol Cell Physiol 298(5): C1140-1150.

117. Khoo, B. L., S. C. Lee, P. Kumar, T. Z. Tan, M. E. Warkiani, S. G. Ow, S. Nandi, C. T. Lim és J. P. Thiery (2015). "Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy." Oncotarget 6(17): 15578-15593.

118. Khuon, S., L. Liang, R. W. Dettman, P. H. Sporn, R. B. Wysolmerski és T. L.

Chew (2010). "Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study."

J Cell Sci 123(Pt 3): 431-440.

119. Kim, B. J., B. M. Hancock, A. Bermudez, N. Del Cid, E. Reyes, N. M. van Sorge, X. Lauth, C. A. Smurthwaite, B. J. Hilton, A. Stotland, A. Banerjee, J. Buchanan, R.

Wolkowicz, D. Traver és K. S. Doran (2015). "Bacterial induction of Snail1 contributes to blood-brain barrier disruption." J Clin Invest 125(6): 2473-2483.

98

120. Kim JH, B. P., Kumar CC. (1993). " Smooth muscle alpha-actin promoter activity is induced by serum stimulation of fibroblast cells." Biochem Biophys ResCommun 190:

1115-1121.

121. Kim JH, J. F., Robertson N, Catino JJ, Prywes R, Kumar CC. (1994).

"Suppression of Ras transformation by serum response factor." J Biol Chem 269: 13740-13743.

122. Kim, K. K., M. C. Kugler, P. J. Wolters, L. Robillard, M. G. Galvez, A. N.

Brumwell, D. Sheppard és H. A. Chapman (2006). "Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix." Proc Natl Acad Sci U S A 103(35): 13180-13185.

123. Kim, T., D. Hwang, D. Lee, J. H. Kim, S. Y. Kim és D. S. Lim (2017). "MRTF potentiates TEAD-YAP transcriptional activity causing metastasis." EMBO J 36(4): 520-535.

124. Kim, Y. S., Z. G. Xu, M. A. Reddy, S. L. Li, L. Lanting, K. Sharma, S. G. Adler és R. Natarajan (2005). "Novel interactions between TGF-{beta}1 actions and the

124. Kim, Y. S., Z. G. Xu, M. A. Reddy, S. L. Li, L. Lanting, K. Sharma, S. G. Adler és R. Natarajan (2005). "Novel interactions between TGF-{beta}1 actions and the