HWE p érték
8. HEALTH STATUS OF YOUNG ADULTS BORN WITH A LOW BIRTH WEIGHT: INVESTIGATION OF THE ASSOCIATION BETWEEN ADRENAL
FUNCTION, CARBOHYDRATE AND BONE HOMEOSTASIS
SUMMARY
Young adults born with a low birth weight (LBW) present a population characterized by altered adrenal function, slight disturbances of glucose homeostasis and accelerated bone turnover. These specific features provide an opportunity to investigate the interactions between adrenal function, insulin regulation and bone homeostasis. During my PhD work I analyzed bone homeostasis parameters (e.g. bone mineral density (BMD), serum osteocalcin (OC), urinary deoxypyridinoline (DPD) excretion), adrenal function (dehidroepiandrosterone-sulphate (DHEAS), cortisol), sex steroid levels (estradiol, testosterone, and sex-hormone binding globulin (SHBG)) along with insulin, DHEA(S) and cortisol response during an oral glucose tolerance test (OGTT) in healthy 19-21 years old people born with normal or low borth weight.
These results suggest that bone turnover depends on the subjects' birth weight and DHEAS levels. The effect of DHEAS on bone turnover is gender dependent. DHEAS increases bone turnover in fertile women, while it decreases this in men. Reactive hyperinsulinemia during OGTT might activate the androgen pathway of adrenal cortex including DHEA production. Therefore acute hyperinsulinemia might counterbalance to some extent the diurnal decrease of DHEA during OGTT.
In an independent study I reanalyzed genotype distributions in 134 papers published between 1998 and 2003 on biallelic genetic variants in the journal of Atherosclerosis.
69 per cent of authors stated that they had performed Hardy-Weinberg equilibrium (HWE) calculations. The distribution of 45 genotypes from 36 papers did not fulfilled HWE criteria. The authors declared the deviation just in 8 cases (6 papers); 30 papers did not mention this fact. This observations warns the interested readers to be cautious when relying to published genetic results and to perform controlling steps to check previous publications
.
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