Nothing is known of the biochemistry of the intracellular forms.
REFERENCES
1. G. M. Findlay, "Recent Advances in Chemotherapy" 3rd ed., Vol. II.
Churchill, London, 1951.
2. T. von Brand, in "Biochemistry and Physiology of Protozoa" (A. Lwoff, ed.), Vol. I, p. 177. Academic Press, N e w York, 1951.
28. TRYPANOCIDAL AGENTS 307 3. L. G. Goodwin and I. M. Rollo in "Biochemistry and Physiology of Pro
tozoa" (S. H. Hutner and A. Lwoff, eds.), Vol. II, p. 225. Academic Press, N e w York, 1955.
4. W. A. Sexton, "Chemical Constitution and Biological Activity," 2nd ed.
Spon, London, 1953.
4a. J. Williamson, Exptl. Parasitol. 12, 274 (1962).
5. M. A. Bechamp, Compt. rend. acad. sci. 56,1172 (1863).
6. H. W. Thomas and A. Breinl, Liverpool School Trop. Med. Mem. 16 (1905).
7. P. Ehrlich, Lancet ii, 445 (1913).
8. Ε . A. H. Friedheim, Am. J. Trop. Med. 29, 173 (1949).
9. H. Eagle and G. 0 . Doak, Pharmacol. Revs. 3, 107 (1951).
10. Ε . A. H. Friedheim, Ann. Trop. Med. Parasitol. 53, 1 (1959).
11. Ε . A. H. Friedheim, Proc. 3rd Intern. Congr. Microbiol., New York p.
428 (1939).
12. J. Le Rouzic, Bull. Med. A. O. F. Spec. No. pp. 53, 63 (1949).
13. P. Ehrlich, Ber. 42,17 (1909).
14. C. Voegtlin, H. A. Dyer, and C. S. Leonard, U.S. Public Health Service Rept. 38, 1882 (1923).
15. C. Voegtlin, H. A. Dyer, and D. W. Miller, J. Pharmacol. Exptl. Therap.
23, 55 (1924).
16. C. Voegtlin, Physiol. Revs. 5, 63 (1925).
16a. F. Hawking, T. J. Hennelly, and J. H. Quastel, J. Pharmacol. Exptl.
Therap. 59, 157 (1937).
17. R. A. Peters and R. W. Wakelin, Biochem. J. 40, 513 (1946).
18. L. A. Stocken and R. H. S. Thompson, Physiol. Revs. 29, 168 (1949).
19. E . S. G. Barron and T. P. Singer, Science 97, 356 (1943).
20. E. S. G. Barron and T. P. Singer, J. Biol. Chem. 157, 221 (1945).
21. C. K. Banks and J. Controulis, J. Am. Chem Soc. 68, 944 (1946).
22. G. R. Seaman, Arch. Biochem. Biophys. 35, 132 (1952).
23. F. Tietze and I. M. Klotz, Arch. Biochem. Biophys. 35, 355 (1952).
24. W. York, F . Murgatroyd, and F. Hawking, Ann. Trop. Med. 25, 351 (1931).
25. H. Eagle and H. J. Magnuson, J. Pharmacol. Exptl. Therap. 82, 137 (1944).
26. N. von Jancso and H. von Jancso, Z. Immunitatsforsch. 88, 275 (1936).
27. V. Fischl and L. Fischl, Z. Immunitatsforsch. 83, 324 (1934).
28. J. Williamson and Ε . M. Lourie, Ann. Trop. Med, 40, 255 (1946).
29. W. I. Schleyer and R. J. Schnitzer, J. Immunol. 60, 265 (1948).
30. J. Williamson and Ε. M. Lourie, Nature 161, 103 (1948).
31. P. Ehrlich and K. Shiga, Berlin klin. Wochschr. pp. 329, 362 (1904).
32. M. Nicolle and F. Mesnil, Ann. inst. Pasteur 20, 417 (1906).
33. I. E. Balaban and H. King, J. Chem. Soc. p. 3068 (1927).
34. E. Fourneau, J. Trefouel, and J. Vallee, Ann. inst. Pasteur 38, 81 (1924).
35. A. Spinks, Biochem. J. 42, 109 (1948).
36. H. von Jancso and N . von Jancso, Zentr. Bakteriol., Parasitenk. Abt. 1 Orig. 132, 257 (1934).
37. F. Hawking and A. B. Sen, Brit. J. Pharmacol. 15, 567 (1960).
38. B. von Fenyvessy and L. Reiner, Biochem. Z. 202, 75 (1928).
308 Β. Α. NEWTON 39. Β. von Issekutz, Arch, exptl. Pathol. Pharmakol. Naunyn-Schmiedeberg's
137,479,499 (1933).
40. F. Glowazky, Z. Hyg. Infektionskrankh. 119, 741 (1937).
41. B. W. Town, E. D. Wills, and A. Wormall, Nature 163, 735 (1949).
42. E. D. Wills and A. Wormall, Biochem. J. 44, xxxix (1949).
43. H. Hoffmann-Berling, Biochim. et Biophys. Acta 16, 146 (1955).
44. N. von Jancso and H. von Jancso, Zentr. Bakteriol. Parasitenk. Abt. I Orig. 132, 257 (1934).
45. W. E . Ormerod, Brit. J. Pharmacol. 6, 334 (1951).
46. H. G. Sen, Β. N . Dutta, and Η. N. Ray, Bull. Calcutta School Trop. Med.
3, 122 (1955).
47. E. D. Wills, Biochem. J. 50, 421 (1952).
48. A. Beilinsohn, Zhur. Eksp. Biol. i Med. 11, 52 (1929).
49. J. H. Quastel, Biochem. J. 25, 1121 (1931).
50. J. M. Beiler and G. J. Martin, J. Biol. Chem. 174, 31 (1948).
51. E . D. Wills, Biochem. J. 57,109 (1954).
52. Α. Ο. M. Stoppani and J. A. Brignone, Arch. Biochem. Biophys. 68, 432 (1957).
53. N. Grubhofer, Z. physiol. Chem. Hoppe-Seyler's 302, 217 (1955).
54. Ε. Ε . B. Smith and G. T. Mills, Biochem. J. 52, i (1952).
55. L. Bergamini and W. Ferrari, Boll. ist. sieroterap. milan. 27, 89 (1948).
56. C. Biot, R. Biot, and C. Richard, Compt. rend. soc. biol. 71, 368 (1911).
57. A. Laveran and F . Mesnil, "Trypanosomes et Trypanosomiasis," 2nd ed.
Masson, Paris, 1912.
58. H. A. Poindexter, J. Parasitol. 21, 292 (1935).
59. N. von Jancso and H. von Jancso, Z. Immunitatsforsch. 86, 1 (1935).
60. K. Schern and R. Artagaveytia-Allende, Z. Immunitatsforsch. 89, 21 (1936).
61. Ε. M. Lourie and W. York, Ann. Trop. Med. Parasitol. 31, 435 (1937).
62. H. King, Ε . M. Lourie, and W. York, Ann. Trop. Med. Parasitol. 32, 177 (1938).
63. J. N. Ashley, H. J. Barber, A. J. Ewins, and A. D. H. Self, J. Chem. Soc.
p. 103 (1942).
64. Ε . B. Schoenbach and Ε. M. Greenspan, Medicine 27, 327 (1948).
65. H. Jensch, ArzneimitteUForsch. 5, 634 (1955).
66. S. R. Christophers and J. D. Fulton, Ann. Trop. Med. Parasitol. 32, 43 (1938).
67. B. von Fenyvessy and L. Reiner, Biochem. Z. 202, 75 (1928).
68. A. Gieger, I. J. Kliger, and R. Comaroff, Ann. Trop. Med. Parasit. 24, 319 (1930).
69. T. von Brand, Ε. M. Johnson, and C. W. Rees, «/. Gen. Physiol. 30, 163 (1946).
70. Ε. M. Lourie and W. York, Ann. Trop. Med. Parasitol. 33, 289 (1939).
71. S. Adler, I. Tchernomoretz, and M. Ber, Ann. Trop. Med. Parasitol. 39, 14 ( 1 9 4 5 ) ; 42, 1 (1948).
72. S. Adler and I. Tchernomoretz, Ann. Trop. Med. Parasitol. 35, 9 (1941).
73. W. O. Elson, J. Infectious Diseases 76, 193 (1945).
74. P. B. Marshall, Brit. J. Pharmacol. 3, 1 (1948).
75. F. Bernheim, Science 98, 223 (1943).
28. TRYPANOCIDAL AGENTS 309 76. F. Bernheim, J. Pharmacol Exptl Therap. 80, 199 (1944).
77. H. Blaschko and R. Duthie, Biochem. J. 39, 347 (1945).
78. A. N. Davison, Bull soc. chim. biol 40, 1737 (1959).
79. A. Amos and E. Vollmayer, J. Bacteriol 73, 172 (1957).
80. R. M. Hicks, Biochim. et Biophys. Acta 46, 143 and 152 (1961).
81. H. Halvorson and L. Ellias, Biochim. et Biophys. Acta 30, 28 (1958).
82. J. Larner and R. E. Gillespie, J. Biol Chem. 223, 709 (1956).
83. Η. I. Kohn, Science 98, 224 (1943).
84. L. Bichowsky, Proc. Soc. Exptl. Biol. Med. 57, 163 (1944).
85. L. Bichowsky-Slomnitzki, J. Bacteriol 55, 27 and 33 (1948).
86. I. Snapper, A. E. Mirsky, H. Ris, B. Schneid, and M. Rosenthal, Blood 2, 311 (1947).
87. Ε. E. Snell, J. Biol Chem. 152, 475 (1944).
88. W. O. Elson, J. Biol Chem. 154, 717 (1944).
89. M. J. Kopac, Cancer Research 7, 44 (1947).
90. D. L. Keister, Federation Proc. 17, 84 (1958).
91. S. Razin and R. Rozansky, Arch. Biochem. Biophys. 81, 36 (1959).
92. A. Fraser and H. R. Mahler, J. Am. Chem. Soc. 80, 6456 (1958).
93. H. R. Mahler, B. D. Mehrotra and C. W. Sharp, Biochem. Biophys. Re-search Communs. 4, 79 (1961).
94. C. E . Chaplin, J. Bacteriol. 64, 805 (1952).
95. R. Fishcher and P. Larose, Nature 170, 715 (1952).
96. B. A. Newton, Symposium Soc. Gen. Microbiol. 8, 62 (1958).
97. P. Mitchell and J. Moyle, J. Gen. Microbiol. 10, 533 (1954).
98. P. Ehrlich and L. Benda, Ber. 46,1931 (1913).
99. R. Schnitzer and W. Silberstein, Z. Hyg. Infektionskrankh. 109, 519 (1929).
100. A. Albert, "The Acridines, Their Preparation, Properties and Uses."
Arnold, London, 1951.
101. G. Morgan, L. P. Walls, C. H. Browning, R. Gulbranson, and J. Μ. V.
Robb, J. Chem. Soc. p. 389 (1938).
102. L. P. Walls, J. Chem. Soc. p. 294 (1945).
103. Τ. I. Watkins and G. Woolfe, Nature 169, 506 (1952).
104. Τ. I. Watkins and G. Woolfe, Nature 178, 368 (1956).
105. W. R. Wragg, K. Washbourn, Κ. N. Brown, and J. Hill, Nature 182, 1005 (1958).
106. J. Williamson and R. S. Desowitz, Nature 177,1074 (1956).
107. J. A. Lock, Brit. J. Pharmacol. 5, 398 (1950).
108. F. Hawking, Symposium on Growth Inhibition and Chemotherapy, p. 88.
6th Intern. Congr. Microbiol., Rome (1953).
109. B. A. Newton, J. Gen. Microbiol. 17, 718 (1957).
110. W. E. Ormerod, Brit. J. Pharmacol 6, 334 (1951).
111. A. E. R. Taylor, Brit. J. Pharmacol. 15, 230 (1960).
112. T. Casperson and K. Brand, Protoplasma 35, 507 (1941).
113. R. Jeener and J. Brachet, Enzymologia 11, 222 (1944).
114. P. C. Caldwell, E. L. Mackor, and C. Hinshelwood, J. Chem. Soc. p. 3151 (1950).
115. E. F. Gale and J. P. Folkes, Biochem. J. 53, 483 (1953).
116. J. H. Barrow, Trans. Am. Microscop. Soc. 73, 242 (1954).
310 Β. Α. NEWTON 117. R. W. H o m e and B. A. Newton, Exptl Cell Research 15, 103 (1958).
118. F. W. Werbitzki, Zentr. Bakteriol, Parasitenk. Orig. 53, 303 (1910).
119. C. A. Hoare, J. Protozool 1, 28 (1954).
120. Η. N. Ray and Μ. N. Malhotra, Nature 188, 870 (1960).
121. A. Seaman and M. Woodbine, Brit. J. Pharmacol. 9, 265 (1954).
122. H. Mcllwain, Biochem. J. 35, 1311 (1941).
123. A. Seaman and M. Woodbine, Proc. 6th Intern. Congr. Microbiol, Rome 1, 636 (1953).
124. E. F. Gale and J. P. Folkes, Biochem. J. 69, 620 (1958).
125. Μ. H. Richmond, Biochim. et Biophys. Acta 34, 325 (1959).
125a. W. H. Elliott, Biochem. J. 86, 562 (1963).
126. L. Dickinson and S. Codd, J. Gen. Microbiol. 6, 1 (1952).
127. L. Dickinson, Β. H. Chantrell, G. W. Inkley, and M. J. Thompson, Brit.
J. Pharmacol. 8, 139 (1953).
128. S. R. Pelc and J. Micou, unpublished observations.
129. L. Goldstein and J. Micou, J. Biophys. Biochem. Cytol 6, 301 (1959).
129a. T. S. Kandaswamy and J. F. Henderson, Nature 195, 85 (1962).
130. A. Albert, S. D. Rubbo, R. Goldacre, M. Davey, and J. Stone, Brit. J.
Exptl. Pathol. 26, 60 (1945).
131. A. Albert, "Selective Toxicity." Metheun, London, 1960.
132. L. S. Lerman, J. Mol. Biol. 3,18 (1961).
133. J. P. Greenstein, "Biochemistry of Cancer." Academic Press, N e w York, 1954.
134. F. H. S. Curd and D. G. Davey, Brit. J. Pharmacol. 5, 25 (1950).
135. B. A. Newton, J. Gen. Microbiol. 19, ii (1958).
136. H. G. Sen, Η. N. Ray, and D. N. Dutta, Bull Calcutta School Trop. Med.
2,18 and 56 (1954).
136a. W. E. Ormerod, Trans. Roy. Soc. Trop. Med. Hyg. 55, 313 (1961).
137. W. E. Ormerod, Brit. J. Pharmacol 6, 325 (1951).
138. B. W. Town, E . D. Wills, and A. Wormall, Nature 164, 233 (1949).
139. B. A. Newton, in "Drugs, Parasites and Hosts" (L. G. Goodwin and R.
H. Nimmo-Smith, eds.), p. 142. Churchill, London, 1962.
140. B. A. Newton, Nature 177, 279 (1956).
141. B. A. Newton, Biochem. J. 77,17P (1960).
142. G. J. Bone and M. Steinert, Nature 178, 308 (1956).
143. J. Williamson and I. M. Rollo, Nature 170, 376 (1952).
144. L. G. Goodwin, in "Strategy of Chemotherapy" (S. T. Cowan and E.
Rowatt, eds.), Symposium Soc. Gen. Microbiol. No. 8, p. 336. Cam
bridge Univ. Press, London and N e w York, 1958.
145. A. Bishop, Biol. Revs. 34, 445 (1959).
146. R. J. Schnitzer and E. Grunberg, "Drug Resistance of Microorganisms."
Academic Press, N e w York, 1957.