Toxicological Sciences
CONTENTS Volume 160, Number 2, December 2017
LOOK INSIDETOXSCI
From the Editor’s Desk, Editor’s Highlights. . . 191 ARSENIC EFFECTS ON GUT MICROBIOME
The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome
Liang Chi, Xiaoming Bian, Bei Gao, Pengcheng Tu, Hongyu Ru, and Kun Lu . . . 193
STRUCTURE ACTIVITY ANALYSIS OF PESTICIDE INTERACTIONS WITH THE THYROID RECEPTOR Editor’s Highlight: Structure-Based Investigation on the Binding and Activation of Typical Pesticides With Thyroid Receptor
Dandan Xiang, Jian Han, Tingting Yao, Qiangwei Wang, Bingsheng Zhou, Abou Donia Mohamed,
and Guonian Zhu. . . 205
PROTECTIVE EFFECTS OF L-CARNITINE ON PFOS-INDUCED KIDNEY DAMAGE
From the Cover:L-Carnitine via PPARg- and Sirt1-Dependent Mechanisms Attenuates Epithelial-Mesenchymal Transition and Renal Fibrosis Caused by Perfluorooctanesulfonate
Hsiu-Chu Chou, Li-Li Wen, Chih-Cheng Chang, Chien-Yu Lin, Lu Jin, and Shu-Hui Juan. . . 217
TCDD EFFECTS ON SEBACEOUS STEM CELLS
From the Cover: High Susceptibility of Lrig1 Sebaceous Stem Cells to TCDD in Mice
Fabienne Fontao, Laurent Barnes, Guerkan Kaya, Jean-Hilaire Saurat, and Olivier Sorg. . . 230
IMPROVED CHEMICAL DESIGN WITH REDUCED TESTICULAR TOXICITY
p-Alkyl-Benzoyl-CoA Conjugates as Relevant Metabolites of Aromatic Aldehydes With Rat Testicular Toxicity—Studies Leading to the Design of a Safer New Fragrance Chemical
Heike Laue, Susanne Kern, Remo P. Badertscher, Graham Ellis, and Andreas Natsch . . . 244
PCB126 AND PERIPHERAL VASCULAR DYSFUNCTION
Editor’s Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model
Banrida Wahlang, Jazmyne Barney, Brendan Thompson, Chunyan Wang, Omer M. Hamad,
Jessie B. Hoffman, Michael C. Petriello, Andrew J. Morris, and Bernhard Hennig. . . 256
LEAD-INDUCED ALTERATION OF MYELOID PROGENITOR FUNCTION
Lead Transiently Promotes Granulocyte-Macrophage Progenitor Differentiation and Subsequently Suppresses Common Myeloid Progenitor Differentiation
Qian Li, Peng Zhang, Xinchun Yu, Yifan Zhao, Qiang Li, Yandong Zhang, Zhengli Yang, Yunli Xie,
Peng Xue, Shuhui Sun, Xiaodong Jia, Zhijun Zhou, Miao He, and Yubin Zhang. . . 268
CHOLINE SUPPLEMENTATION DOES NOT ATTENUATE PFOS-INDUCED HEPATIC STEATOSIS
Perfluorooctane Sulfonate-Induced Hepatic Steatosis in Male Sprague Dawley Rats Is Not Attenuated by Dietary Choline Supplementation
Bradford D. Bagley, Shu-Ching Chang, David J. Ehresman, Alan Eveland, Jeremiah D. Zitzow,
George A. Parker, Jeffrey M. Peters, Kendall B. Wallace, and John L. Butenhoff. . . 284
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REPRODUCTIVE TOXICITY OF 1,2-DICHLOROETHANE
1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice
Yating Zhang, Guoliang Li, Yizhou Zhong, Manqi Huang, Jiejiao Wu, Jiewei Zheng, Weifeng Rong, Lihai Zeng, Xiao Yin, Fengrong Lu, Zhiwei Xie, Dandan Xu, Qiming Fan, Xiaohui Jia, Ting Wang,
Qiansheng Hu, Wen Chen, Qing Wang, and Zhenlie Huang. . . 299
ROLE OF ANGII SIGNALING IN ARSENITE-INDUCED VASCULAR ENDOTHELIAL CELL DYSFUNCTION Arsenite Induces Vascular Endothelial Cell Dysfunction by Activating IRE1a/XBP1s/HIF1a-Dependent ANGII Signaling
Xiuduan Xu, Shasha Liu, Aodengqimuge, Hongli Wang, Meiru Hu, Chen Xing, and Lun Song . . . 315
EFFECTS OF ZIRAM ON RAT LEYDIG CELL DEVELOPMENT Ziram Delays Pubertal Development of Rat Leydig Cells
Xiaoling Guo, Songyi Zhou, Yong Chen, Xianwu Chen, Jianpeng Liu, Fei Ge, Qingquan Lian, Xiaomin Chen,
and Ren-Shan Ge. . . 329
PROTECTIVE EFFECTS OF L-CARNITINE IN ISCHEMIC HEART INJURY
L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang,
Courtney Cates, Thomas Rousselle, and Ji Li. . . 341
PPARa-MEDIATED REDUCTION OF BILE ACIDS BY CLOFIBRATE
Editor’s Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARa-Dependent Manner
Youcai Zhang, Andrew J. Lickteig, Iva´n L. Csanaky, and Curtis D. Klaassen. . . 351
MACHINE LEARNING ANALYSIS OF PYRROLIZIDINE ALKALOID-INDUCED HEPATOTOXICITY Editor’s Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks
Verena Scho¨ning, Felix Hammann, Mark Peinl, and Ju¨rgen Drewe. . . 361
EFFECTS OF BISPHENOL A IN FEMALE CHILDREN MEASURED BY HIGH-RESOLUTION METABOLOMICS Elevated Metabolites of Steroidogenesis and Amino Acid Metabolism in Preadolescent Female Children With High Urinary Bisphenol A Levels: A High-Resolution Metabolomics Study
Adnan Khan, Hyesook Park, Hye Ah Lee, Bohyun Park, Hye Sun Gwak, Hye-Ra Lee, Sun Ha Jee,
and Youngja H. Park. . . 371
DEVELOPMENTAL EXPOSURE TO PCB126 REPROGRAMS BRAIN GENE EXPRESSION
Early Life Exposure to Low Levels of AHR Agonist PCB126 (3,30,4,40,5-Pentachlorobiphenyl) Reprograms Gene Expression in Adult Brain
Neelakanteswar Aluru, Sibel I. Karchner, and Lilah Glazer . . . 386
BRAIN PENETRATION STUDIES OF THE NOVEL CYANIDE ANTIDOTE DIMETHYL TRISULFIDE From the Cover:In VitroandIn VivoBlood-Brain Barrier Penetration Studies with the Novel Cyanide Antidote Candidate Dimethyl Trisulfide in Mice
Lo´ra´nd Kiss, Alexandra Bocsik, Fruzsina R. Walter, James Ross, Denise Brown, Brooke A. Mendenhall, Sarah R. Crews, Jana Lowry, Valerie Coronado, David E. Thompson, Peter Sipos, Piroska Szabo´-Re´ve´sz,
Ma´ria A. Deli, and Ilona Petrikovics. . . 398
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DEVELOPMENT OF AN ARYL HYDROCARBON ACTIVATION ASSAY
From the Cover: Development and Application of a Dual Rat and Human AHR Activation Assay Martin R. Brown, Helen Garside, Emma Thompson, Saseela Atwal, Chloe Bean, Tony Goodall,
Michael Sullivan, and Mark J. Graham . . . 408
CORNEAL DAMAGE FROM THE VESICANT LEWISITE
Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure
Neera Tewari-Singh, Dinesh G. Goswami, Rama Kant, David A. Ammar, Dileep Kumar,
Robert W. Enzenauer, Robert P. Casillas, Claire R. Croutch, J. Mark Petrash, and Rajesh Agarwal. . . 420
CORRIGENDUM
L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang,
Courtney Cates, Thomas Rousselle, and Ji Li. . . 429
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