25th International Symposium on Analytical and Environmental Problems
147
ANTIMICROBIAL EFFECT OF SOME NEW SALICYLAMIDE DERIVATIVES Ienaşcu, I.M.C.1,2, Căta, A.1, Ştefănuţ, M.N.1, Obistioiu, D.3, Popescu, I.M.4
1National Institute of Research and Development for Electrochemistry and Condensed Matter, 144 Dr. A. P. Podeanu, 300569, Timişoara, Romania
2“Vasile Goldiş” Western University of Arad, Faculty of Pharmacy, Department of Pharmaceutical Sciences, 86 Liviu Rebreanu, 310045, Arad, Romania
3Banat’s Agricultural Science University, Faculty of Agriculture, Interdisciplinary Research Platform, 119 Calea Aradului, 300645, Timişoara, Romania
4Banat’s Agricultural Science University, Faculty of Agriculture, Department of Chemistry and Biochemistry, 119 Calea Aradului, 300645, Timişoara, Romania
imcienascu@yahoo.com
Abstract
New 5-chloro-2-hydroxy-benzamide derivatives, esters, hydrazides, hydrazones, were obtained in good yields (60-93%), using conventional heating synthesis. The obtaining pathways of the synthesized compounds are presented in figure 1.
OH
CO NH2 CH2 Cl
K2CO3 MEC
C O
OR O
CO NH2
Cl CH2 C
O OR
Cl
R=C2H5, CH3
1,2
H2N NH2
EtOH abs.
O
CO NH2
Cl CH2 C
O
NH NH2 O
CO NH2
Cl CH2 C
O NH N H
C R1
R2
EtOH abs.
OHC R1
R2 R3
R1=OH, H; R2= Br, H; R3= H, N(CH3)2
R3
3 4,5
0
Figure 1. The obtaining pathways of the synthesized compounds
The synthesized compunds were characterized using modern physico-chemical methods (FTIR, 1H- and 13C-NMR), the obtained results demonstrated the compounds identity.
The antimicrobial activity of the compounds was tested against some bacterial strains, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus mutans, Escherichia coli, by measuring the optical density at 540 nm. The most effective compound was 5-chloro-2- hydrazinocarbonylmethoxy-benzamide and the most sensitive strain to the action of the tested compounds was Staphylococcus aureus. The tested compounds presented no inhibitory effect on Escherichia coli.
Acknowledgements
This work is part of the project PN 19 22 03 01 / 2019 “Supramolecular inclusion complexes of some natural and synthetic compounds with health applications”, carried out under NUCLEU Program funded by National Authority for Scientific Research (Romania).
References
[1] J. Matyk, K. Waisser, K. Drazkova, J. Kunes, V. Klimensova, K. Palat, J. Kaustova, Farmaco. 60(5) (2005) 399.
[2] K. Waisser, J. Matyk, H. Divisova, P. Husakova, J. Kunes, V. Klimensova, J. Kaustova, U. Mollmann, H.M. Dahse, M. Miko, Arch Pharm. 339(11) (2006) 616.
